ReviewBio Systems2019
Experimental solutions to problems defining the origin of codon-directed protein synthesis.
Review in Bio Systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology.Genome biology and evolution · 2025Article
- A genomic database furnishes minimal functional glycyl-tRNA synthetases homologous to other, designed class II urzymes.Nucleic acids research · 2024Article
- Primordial aminoacyl-tRNA synthetases preferred minihelices to full-length tRNA.Nucleic acids research · 2024Article
- Base Pairing Promoted the Self-Organization of Genetic Coding, Catalysis, and Free-Energy Transduction.Life (Basel, Switzerland) · 2024Review
- Genomic database furnishes a spontaneous example of a functional Class II glycyl-tRNA synthetase urzyme.bioRxiv : the preprint server for biology · 2024Article
- From the RNA-Peptide World: Prebiotic Reaction Conditions Compatible with Lipid Membranes for the Formation of Lipophilic Random Peptides in the Presence of Short Oligonucleotides, and More.Life (Basel, Switzerland) · 2024Article
- Origins of Genetic Coding: Self-Guided Molecular Self-Organisation.Entropy (Basel, Switzerland) · 2023Article
- Domain acquisition by class I aminoacyl-tRNA synthetase urzymes coordinated the catalytic functions of HVGH and KMSKS motifs.Nucleic acids research · 2023Article
- Mixed anhydrides at the intersection between peptide and RNA autocatalytic sets: evolution of biological coding.Interface focus · 2023Article
- A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5'AMP.International journal of molecular sciences · 2022Article
- Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.Nucleic acids research · 2021Article
- Reciprocally-Coupled Gating: Strange Loops in Bioenergetics, Genetics, and Catalysis.Biomolecules · 2021Review
- Impedance Matching and the Choice Between Alternative Pathways for the Origin of Genetic Coding.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
How genetic coding differentiated biology from chemistry is a long-standing challenge in Biology, for which there have been few experimental approaches, despite a wide-ranging speculative literature. We summarize five coordinated areas-experimental characterization of functional approximations to the minimal peptides (protozymes and urzymes) necessary to activate amino acids and acylate tRNA; showing that specificities of these experimental models match those expected from the synthetase Class division; population of disjoint regions of amino acid sequence space via bidirectional coding ancestry of the two synthetase Classes; showing that the phase transfer equilibria of amino acid side chains that form a two-dimensional basis set for protein folding are embedded in patterns of bases in the tRNA acceptor stem and anticodon; and identification of molecular signatures of ancestral synthetases and tRNAs necessary to define the earliest cognate synthetase:tRNA pairs-that now compose an extensive experimentally testable paradigm for progress toward understanding the coordinated emergence of the codon table and viable mRNA coding sequences. We briefly discuss recent progress toward identifying the remaining outstanding questions-the nature of the earliest amino acid alphabets and the origin of binding discrimination via distinct amino acid sequence-independent protein secondary structures-and how these, too, might be addressed experimentally.
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Registered trials
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