Evidence map›Paper›PMID 31176730›Full record

ArticleGene2019

Circulating microRNA-23b as a new biomarker for rheumatoid arthritis.

Xi Liu, Su Ni, Chenkai Li, Nanwei Xu, Wenyang Chen, Min Wu, Andre J van Wijnen, Yuji Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  10. The role of miRNAs in Behçet's disease.Frontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xi LiuDepartment of Rheumatology, The First People's Hospital of Changhzhou, The Third Affiliated Hospital of Soochow University, 185 Juqian Road, Changzhou 213003, China; Department of Rheumatology, The People's Hospital of Jianyang City, 180 Yiyuan Road, Jianyang 641400, China.
Su NiMedical Research Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, China.
Chenkai LiMedical Research Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, China.
Nanwei XuDepartment of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, China.
Wenyang ChenMedical Research Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, China.
Min WuDepartment of Rheumatology, The First People's Hospital of Changhzhou, The Third Affiliated Hospital of Soochow University, 185 Juqian Road, Changzhou 213003, China.
Andre J van WijnenDepartment of Orthopedic Surgery and Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: vanwijnen.andre@mayo.edu.
Yuji WangDepartment of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, China; Department of Orthopedic Surgery and Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: wang.yuji@mayo.edu.
Changzhou No.2 People's Hospital · CNSoochow University · CNMayo Clinic · USMayo Clinic in Arizona · US

Funding

Molecular Control of Bone FormationR01AR049069 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WESTENDORF, JENNIFER J · 2003 to 2021
$5.8M
NIAMS NIH HHS R01 AR049069
6 · The paper itself

Abstract

MicroRNA-23b (miR-23b) is associated with inflammation and autoimmune diseases. This study evaluated miR-23b expression and assessed its potential as a biomarker of disease activity for rheumatoid arthritis (RA). Differential expression of microRNAs was determined by miRNA microarray analysis in fibroblast-like synoviocytes (FLSs) from four trauma patients as healthy controls (HCs) and eight RA patients. The microarray results showed elevated expression of miR-23b in FLSs from RA patients and this finding was corroborated by real-time quantitative polymerase chain reaction (RT-qPCR) and in situ hybridization using synovial tissues (STs). Furthermore, we found miR-23b levels in plasma of RA patients were significantly higher than in HCs, and plasma miR-23b levels positively correlated with the erythrocyte sedimentation rate (ESR), hypersensitive C-reactive protein (hs-CRP), C-reactive protein (CRP), DAS28, and platelet (PLT) count (P < 0.05). MiR-23b levels in plasma inversely correlated with the levels of hemoglobin (Hb), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P < 0.05), but not with rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibodies (ACPA) (P > 0.05). Moreover, patients with anorexia showed higher levels of miR-23b in plasma than those without anorexia. Similar results were observed with fatigue. Appropriate treatment for RA not only ameliorated the disease condition but also reversed the elevated plasma miR-23b level remarkably. These results suggest that circulating miR-23b may be a promising biomarker for RA disease activity.

Indexed as

AdultAgedAnti-Citrullinated Protein AntibodiesArthritis, RheumatoidBilirubinBiomarkersBlood SedimentationCholesterolCholesterol, LDLC-Reactive ProteinFemaleFibroblastsGene Expression ProfilingGene Expression RegulationHemoglobinsHumansAnti-Citrullinated Protein AntibodiesBilirubinBiomarkersCholesterolCholesterol, LDLC-Reactive ProteinHemoglobinsMicroRNAsMIRN23a microRNA, humanRheumatoid FactorBiomarkerCirculating microRNA-23bRheumatoid arthritis

Identifiers

PMID31176730
PMCPMC6724744
OpenAlexW2949382397

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.