Evidence map›Paper›PMID 31176262›Full record

ArticleRedox biology2019

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells.

Adam Y Xiao, Matthew R Maynard, Cortt G Piett, Zachary D Nagel, J Steven Alexander, Christopher G Kevil, Michael V Berridge, Christopher B Pattillo, Lane R Rosen, Sumitra Miriyala and 1 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
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  7. Article
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  9. Self-Assembled Aza-Boron-Dipyrromethene-Based HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Mitochondrial DNA Alterations in Glioblastoma (GBM).International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Adam Y XiaoDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.
Matthew R MaynardRadiation Oncology, Willis-Knighton Cancer Center, Shreveport, LA, 71103, USA.
Cortt G PiettHarvard University, School of Public Health, Boston, MA, 02115, USA.
Zachary D NagelHarvard University, School of Public Health, Boston, MA, 02115, USA.
J Steven AlexanderDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.
Christopher G KevilDepartment of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.
Michael V BerridgeMalaghan Institute of Medical Research, Wellington, 6242, New Zealand.
Christopher B PattilloDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.
Lane R RosenRadiation Oncology, Willis-Knighton Cancer Center, Shreveport, LA, 71103, USA.
Sumitra MiriyalaDepartment of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA.
Lynn HarrisonDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA. Electronic address: lclary@lsuhsc.edu.
Louisiana State University Health Sciences Center Shreveport · USHarvard University · USWillis-Knighton Cancer Center · USMalaghan Institute of Medical Research · NZ

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6M
Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
NCI NIH HHS P01 CA092584NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

Glioblastoma (GBM) has a poor prognosis despite intensive treatment with surgery and chemoradiotherapy. Previous studies using dose-escalated radiotherapy have demonstrated improved survival; however, increased rates of radionecrosis have limited its use. Development of radiosensitizers could improve patient outcome. In the present study, we report the use of sodium sulfide (Na

Indexed as

ApoptosisCell LineCell Line, TumorDNA DamageDNA RepairEndothelial CellsHumansHydrogen SulfideMitochondriaNeurogliaOrgan SpecificityOxidative PhosphorylationOxidative StressPhotonsProton TherapyRadiation-Sensitizing AgentsHydrogen SulfideRadiation-Sensitizing AgentsReactive Oxygen Speciessodium sulfideSulfidesDNA damageDNA repairGlioblastomaHydrogen sulfideIonizing radiationMitochondriaReactive oxygen species

Identifiers

PMID31176262
PMCPMC6556549
OpenAlexW2945466041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.