Evidence map›Paper›PMID 31176175›Full record

ReviewCurrent opinion in cell biology2019

Protein phase separation in mitosis.

Ashish Kumar Tiwary, Yixian Zheng

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Protein conformation and biomolecular condensates.Current research in structural biology · 2022
    Review
  14. Self-Organization of Cellular Units.Annual review of cell and developmental biology · 2021
    Review
  15. Article
  16. Article
  17. Protein phase separation: A novel therapy for cancer?British journal of pharmacology · 2020
    Review
  18. Review
  19. Membrane and organelle dynamics during cell division.Nature reviews. Molecular cell biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashish Kumar TiwaryDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States.
Yixian ZhengDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States. Electronic address: zheng@carnegiescience.edu.

Funding

Super-resolution microscopy of nuclear lamin and spindle envelope/matrix functionR01GM106023 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI GOLDMAN, ROBERT D, ZHENG, YIXIAN · 2013 to 2020
$3.5M
The function and assembly of the lamin-B spindle sheathR01GM056312 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI ZHENG, YIXIAN · 1997 to 2014
$2.7M
Mechanisms of chromosome segregation and mitotic timingR01GM110151 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI ZHENG, YIXIAN · 2015 to 2018
$1.5M
NIGMS NIH HHS R01 GM056312NIGMS NIH HHS R01 GM106023NIGMS NIH HHS R01 GM110151
6 · The paper itself

Abstract

Through phase separation, some proteins form liquid-like condensates or droplets which can flow, fuse, and even deform when pressure is applied. In some cases, the condensates 'mature' to form gel or solid-like structure. Recent studies suggest that the liquid-like condensates form the structural basis for several membrane-less subcellular organelles such as stress granules and other subcellular structures. Here, we review and discuss studies that implicate protein phase separation in the function of the spindle apparatus and centrosomes.

Indexed as

MitosisAmino Acid SequenceAnimalsCentrosomeHumansMicrotubulesOrganellesProteinsSpindle ApparatusProteins

Identifiers

PMID31176175
PMCPMC6756948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.