Evidence map›Paper›PMID 31176069›Full record

ReviewCurrent opinion in virology2019

Curious entanglements: interactions between mosquitoes, their microbiota, and arboviruses.

Eric P Caragata, Chinmay V Tikhe, George Dimopoulos

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Microbiota variation inMicrobiology spectrum · 2026
    Article
  3. Horizons of the Future: Preparedness and Response.Current topics in microbiology and immunology · 2026
    Review
  4. Detection of novelFrontiers in microbiology · 2026
    Article
  5. Review
  6. Article
  7. Identification of anFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Characterization of the Tissue and Strain-Specific Microbiota ofTropical medicine and infectious disease · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eric P CaragataW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Chinmay V TikheW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
George DimopoulosW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States. Electronic address: gdimopo1@jhu.edu.
Johns Hopkins University · US

Funding

Aedes antiviral RNAi pathwayR01AI141532 · NIAID · JOHNS HOPKINS UNIVERSITY · PI George Dimopoulos, KEVIN M MYLES · 2019 to 2026
$4.6M
Dissection of Anopheles Responses to Plasmodium Infected BloodR01AI061576 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2005 to 2014
$3.8M
MicroRNA regulation of Anopheles immunity to PlasmodiumR01AI122743 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DIMOPOULOS, GEORGE, ZHU, JINSONG · 2016 to 2020
$3.3M
Targeting chemosensory signaling in Aedes aegypti mosquitoesR01AI121253 · NIAID · UNIVERSITY OF COLORADO DENVER · PI JONES, DAVID NIGEL · 2016 to 2020
$2.4M
Dscam function in innate immunityR01AI081877 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2010 to 2014
$1.6M
Aedes anti-dengue immunityR01AI078997 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2009 to 2010
$805k
Zika and dengue virus agonists for transmission-blockingR21AI136456 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2018 to 2019
$450k
Plasmodium agonists for transmission-blockingR21AI131574 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DIMOPOULOS, GEORGE · 2017 to 2018
$450k
NIAID NIH HHS R01 AI061576NIAID NIH HHS R01 AI078997NIAID NIH HHS R01 AI081877NIAID NIH HHS R01 AI121253NIAID NIH HHS R01 AI122743NIAID NIH HHS R01 AI141532NIAID NIH HHS R21 AI131574NIAID NIH HHS R21 AI136456
6 · The paper itself

Abstract

Mosquitoes naturally harbor a diverse community of microorganisms that play a crucial role in their biology. Mosquito-microbiota interactions are abundant and complex. They can dramatically alter the mosquito immune response, and impede or enhance a mosquito's ability to transmit medically important arboviral pathogens. Yet critically, given the massive public health impact of arboviral disease, few such interactions have been well characterized. In this review, we describe the current state of knowledge of the role of microorganisms in mosquito biology, how microbial-induced changes to mosquito immunity moderate infection with arboviruses, cases of mosquito-microbial-virus interactions with a defined mechanism, and the molecular interactions that underlie the endosymbiotic bacterium Wolbachia's ability to block virus infection in mosquitoes.

Indexed as

Mosquito VectorsAedesAnimalsAnophelesArbovirusesArbovirus InfectionsBiological Control AgentsCulexDengue VirusHost Microbial InteractionsHumansImmunity, InnateMicrobial InteractionsMicrobiotaVirus DiseasesWolbachiaBiological Control Agents

Identifiers

PMID31176069
PMCPMC6768729
OpenAlexW2956155433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.