ArticleNeurobiology of disease2019
Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain.
Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Refined protocol for quantifying hippocampal neurogenesis in organotypic slice cultures.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Article
- Repeated sevoflurane exposure causes hypomyelination in the prefrontal cortex of adult male mice.Scientific reports · 2025Article
- Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions.Pediatric radiology · 2024Review
- Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Gut Microbiota-Metabolite-Brain Axis Reconstitution Reverses Sevoflurane-Induced Social and Synaptic Deficits in Neonatal Mice.Research (Washington, D.C.) · 2024Article
- Early life phenobarbital exposure dysregulates the hippocampal transcriptome.Frontiers in pharmacology · 2024Article
- Bumetanide attenuates sevoflurane-induced neuroapoptosis in the developing dentate gyrus and impaired behavior in the contextual fear discrimination learning test.Brain and behavior · 2022Article
- Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.Neurobiology of disease · 2022Article
- Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway.Frontiers in neuroscience · 2022Article
- Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids.Frontiers in cell and developmental biology · 2022Article
- Neonatal anesthesia and dysregulation of the epigenome†.Biology of reproduction · 2021Review
- Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia.Seminars in fetal & neonatal medicine · 2021Review
- Neurocritical Care of the Pregnant Patient.Current treatment options in neurology · 2021Review
- Effects of neonatal isoflurane anesthesia exposure on learning-specific and sensory systems in adults.Scientific reports · 2020Article
- Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review.British journal of anaesthesia · 2020Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends from the third trimester of pregnancy to the third year of life. Despite all concerns, there is no ethically and medically acceptable alternative to the use of sedatives and anesthetics for surgeries and painful interventions. Development of measures that prevent injury while allowing the medications to exert their desired actions has enormous translational value. Here we investigated protective potential of hypothermia against histological toxicity of the anesthetic sevoflurane in the developing nonhuman primate brain. Neonatal rhesus monkeys underwent sevoflurane anesthesia over 5 h. Body temperature was regulated in the normothermic (>36.5 °C), mild hypothermic (35-36.5 °C) and moderately hypothermic (<35 °C) range. Animals were euthanized at 8 h and brains examined immunohistochemically (activated caspase 3) and stereologically to quantify apoptotic neuronal and oligodendroglial death. Sevoflurane anesthesia was well tolerated at all temperatures, with oxygen saturations, end tidal CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.