ReviewFrontiers in neuroendocrinology2019
Bundling the haystack to find the needle: Challenges and opportunities in modeling risk and resilience following early life stress.
Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Early-life adversity shapes anomalous spontaneous behavior in mice heterozygous for Cntnap2.Translational psychiatry · 2026Article
- Sensitive windows, sensitive outcomes: Early or late-postnatal maternal separation differentially impacts puberty and behavior.Neurobiology of stress · 2026Article
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- N-acetylcysteine Restores Impaired Dentate Gyrus Neurogenesis in a Neonatal Maternal Separation Rat Model.Experimental neurobiology · 2025Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2.Neurobiology of stress · 2025Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
- One week of maternal separation induces more frequent, but less predictable, maternal caregiving behaviors.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2022Article
- Enduring disruption of reward and stress circuit activities by early-life adversity in male rats.Translational psychiatry · 2022Article
- Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.The European journal of neuroscience · 2022Review
- Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.Developmental psychobiology · 2022Article
- At the Crossroad Between Resiliency and Fragility: A Neurodevelopmental Perspective on Early-Life Experiences.Frontiers in cellular neuroscience · 2022Review
- Using animal models for the studies of schizophrenia and depression: The value of translational models for treatment and prevention.Frontiers in behavioral neuroscience · 2022Review
- Age- and sex-specific effects of maternal separation on the acoustic startle reflex in rats: early baseline enhancement in females and blunted response to ambiguous threat.Frontiers in behavioral neuroscience · 2022Article
- Mice Born to Mothers with Gravida Traumatic Brain Injury Have Distorted Brain Circuitry and Altered Immune Responses.Journal of neurotrauma · 2021Article
- Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats.Developmental psychobiology · 2021Article
- Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- The social ecology of childhood and early life adversity.Pediatric research · 2021Review
- The Developmental Origins of Opioid Use Disorder and Its Comorbidities.Frontiers in human neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Various forms of early life adversity (ELA) have been linked with increased risk for negative health outcomes, including neuropsychiatric disorders. Understanding how the complex interplay between types, timing, duration, and severity of ELA, together with individual differences in genetic, socio-cultural, and physiological differences can mediate risk and resilience has proven difficult in population based studies. Use of animal models provides a powerful toolset to isolate key variables underlying risk for altered neural and behavioral maturational trajectories. However, a lack of clarity regarding the unique features of differing forms of adversity, lab differences in the implementation and reporting of methods, and the ability compare across labs and types of ELA has led to some confusion. Here, we highlight the diversity of approaches available, current challenges, and a possible ways forward to increase clarity and drive more meaningful and fruitful implementation and comparison of these approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.