Evidence map›Paper›PMID 31175843›Full record

ReviewExperimental neurology2019

Imaging spinal cord activity in behaving animals.

Nicholas A Nelson, Xiang Wang, Daniela Cook, Erin M Carey, Axel Nimmerjahn

Abstract readReview
In one paragraph

Review in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026
    Review
  2. Spike rate inference from mouse spinal cord calcium imaging data.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Neural regeneration research · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Astrocytes and Microglia Exhibit Cell-Specific CaFrontiers in molecular neuroscience · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas A NelsonWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Biologial Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA.
Xiang WangWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Daniela CookWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Erin M CareyWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Axel NimmerjahnWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: animmerj@salk.edu.

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Salk Institute for Biological Studies NINDS Center Core GrantP30NS072031 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D · 2011 to 2015
$4.2M
Genetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animalsU01NS103522 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NIMMERJAHN, AXEL, TIAN, LIN · 2017 to 2019
$2.9M
Elucidating cellular activity patterns underlying spinal cord functionR01NS108034 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI NIMMERJAHN, AXEL · 2019 to 2022
$1.7M
Overcoming barriers in the study of in vivo spinal cord functionR01NS085938 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI NIMMERJAHN, AXEL · 2013 to 2016
$1.4M
Opioid Sensitive GABA inputs to the Ventral MidbrainR01DA034388 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 2012 to 2016
$967k
NCI NIH HHS P30 CA014195NIDA NIH HHS R01 DA034388NINDS NIH HHS P30 NS072031NINDS NIH HHS R01 NS085938NINDS NIH HHS R01 NS108034NINDS NIH HHS U01 NS103522
6 · The paper itself

Abstract

The spinal cord is the primary neurological link between the brain and peripheral organs. How important it is in everyday life is apparent in patients with spinal cord injury or motoneuron disease, who have dramatically reduced musculoskeletal control or capacity to sense their environment. Despite its crucial role in sensory and motor processing little is known about the cellular and molecular signaling events that underlie spinal cord function under naturalistic conditions. While genetic, electrophysiological, pharmacological, and circuit tracing studies have revealed important roles for different molecularly defined neurons, these approaches insufficiently describe the moment-to-moment neuronal and non-neuronal activity patterns that underlie sensory-guided motor behaviors in health and disease. The recent development of imaging methods for real-time interrogation of cellular activity in the spinal cord of behaving mice has removed longstanding technical obstacles to spinal cord research and allowed new insight into how different cell types encode sensory information from mechanoreceptors and nociceptors in the skin. Here, we review the current state-of-the-art in interrogating cellular and microcircuit function in the spinal cord of behaving mammals and discuss current opportunities and technological challenges.

Indexed as

AnimalsBehavior, AnimalNeuroimagingSpinal CordAstrocyteBehaviorCalcium imagingMiniature microscopeMotor systemMulti-photon microscopeNeuronNociceptionSensory systemSpinal cord

Identifiers

PMID31175843
PMCPMC7840222

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.