Evidence map›Paper›PMID 31175700›Full record

ReviewStem cells (Dayton, Ohio)2019

Concise Review: A Critical Evaluation of Criteria Used to Define Salivary Gland Stem Cells.

Pei-Lun Weng, Marit H Aure, Catherine E Ovitt

Abstract readReview
In one paragraph

Review in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022
    Review
  9. Review
  10. Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pei-Lun WengDepartment of Dermatology, Yale University, New Haven, Connecticut, USA.
Marit H AureMatrix and Morphology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Catherine E OvittCenter for Oral Biology, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.ORCID 0000-0002-8045-3119

Funding

Cell Based Regeneration of Salivary GlandsR01DE022949 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE · 2012 to 2015
$1.5M
Salivary gland-specific radioprotectionR56DE025098 · NIDCR · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., OVITT, CATHERINE · 2016 to 2016
$531k
NIDCR NIH HHS R01 DE022949NIDCR NIH HHS R56 DE025098
6 · The paper itself

Abstract

In the effort to develop cell-based therapies to treat salivary gland dysfunction, many different populations of cells in the adult salivary glands have been proposed as stem cells. These cell populations vary, depending on the assay used, and are often nonoverlapping, leading to the conclusion that salivary glands harbor multiple stem cells. The goal of this review is to critically appraise the assays and properties used to identify stem cells in the adult salivary gland, and to consider the caveats of each. Re-evaluation of the defining criteria may help to reconcile the many potential stem cell populations described in the salivary gland, in order to increase comparability between studies and build consensus in the field. Stem Cells 2019;37:1144-1150.

Indexed as

AdultBiomarkersCell DifferentiationCell LineageCell ProliferationCell Self RenewalHumansSalivary GlandsStem CellsStem Cell TransplantationBiomarkersAcinarLineage-restrictedProgenitor cellSalivary glandStem cell

Identifiers

PMID31175700
PMCPMC6711783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.