ArticleJournal of veterinary internal medicine2019
Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The comparison of acute phase proteins in experimentally induced canine acute pancreatitis.BMC veterinary research · 2026Article
- Apolipoprotein A-1 does not appear to be a suitable acute-phase reaction marker in canine babesiosis and hemoplasmosis.Current research in parasitology & vector-borne diseases · 2025Article
- (Un)Tying the Knot: Oxidative Stress, Inflammatory Markers, and Lipid Status in Dogs with Hypercortisolism.Animals : an open access journal from MDPI · 2024Article
- Serum proteome profiling of naturally acquired Babesia rossi infection in dogs.Scientific reports · 2023Article
- Reduced Cholesterol Levels during Acute Human Babesiosis.Pathogens (Basel, Switzerland) · 2023Article
- Spurious capillary zone electrophoresis pattern in hypercholesterolemic dogs.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Apolipoprotein A1 and serum amyloid A in dogs with sepsis and septic shock.Frontiers in veterinary science · 2023Article
- Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2022Article
- Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis.International journal of biometeorology · 2022Article
- Molecular Identification and Genotyping of Babesia canis in Dogs from Meshkin Shahr County, Northwestern Iran.Journal of arthropod-borne diseases · 2021Article
- Review
- Evaluation of Serum Apolipoprotein A1 in Canine Sepsis.Frontiers in veterinary science · 2020Article
- Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs.Journal of veterinary internal medicine · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBabesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. HYPOTHESIS: Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. ANIMALS: Twenty-nine client-owned dogs with acute B. canis infection and 10 clinically healthy control dogs.
methodsObservational cross-sectional study. Serum amyloid A (SAA) was measured using ELISA. Cholesterol, phospholipids, and triglycerides were determined biochemically. Lipoproteins were separated using agarose gel electrophoresis. Lipoprotein diameter was assessed by polyacrylamide gradient gel electrophoresis; correlation with ApoA-1 (radioimmunoassay) and SAA was determined.
resultsDogs with B. canis infection had a marked APR (median SAA, 168.3 μg/mL; range, 98.1-716.2 μg/mL) compared with controls (3.2 μg/mL, 2.0-4.2 μg/mL) (P < .001). Dogs with B. canis infection had significantly lower median cholesterol (4.79 mmol/L, 1.89-7.64 mmol/L versus 6.15 mmol/L, 4.2-7.4 mmol/L) (P = .02), phospholipid (4.64 mmol/L, 2.6-6.6 mmol/L versus 5.72 mmol/L, 4.68-7.0 mmol/L) (P = .02), and α-lipoproteins (77.5%, 27.7%-93.5% versus 89.2%, 75.1%-93.5%) (P = .04), and higher ApoA-1 (1.36 U, 0.8-2.56 U versus 0.95 U, 0.73-1.54 U) concentrations (P = .02). Serum amyloid A correlated with high-density lipoproteins (HDLs) diameter (rho = .43; P = .03) and ApoA-1 (rho = .63, P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Major changes associated with B. canis-induced APR in dogs are related to concentration, composition, and morphology of HDL particles pointing to an altered reverse cholesterol transport. Parallel ApoA-1 and SAA concentration increase is a unique still unexplained pathophysiological finding.
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