Trial reportPrevention science : the official journal of the Society for Prevention Research2019
The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial.
Trial report in Prevention science : the official journal of the Society for Prevention Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Genotype-environment correlation by intervention effects underlying middle childhood peer rejection and associations with adolescent marijuana use.Development and psychopathology · 2022Trial
- Genomic insights into substance use and disinhibitory disorders.medRxiv : the preprint server for health sciences · 2026Article
- Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Disentangling developmental trajectories of childhood anxiety and depression symptoms in the prediction of adolescent substance use.European child & adolescent psychiatry · 2025Article
- The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.Development and psychopathology · 2023Article
- A Lifestyle Risk Reduction Model for Preventing High-Risk Substance Use Across the Lifespan.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- A gene-environment cascade theoretical framework of developmental psychopathology.Journal of psychopathology and clinical science · 2023Article
- An in-laboratory stressor reveals unique genetic variation in child cortisol output.Developmental psychology · 2022Article
- Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults.Journal of youth and adolescence · 2022Article
- Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022Article
- Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention.Behavior genetics · 2021Article
- "Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era.Annual review of psychology · 2021Review
- Polygenic Scores in Developmental Psychology: Invite Genetics In, Leave Biodeterminism Behind.Annual review of developmental psychology · 2020Article
- Intergenerational congruence in adolescent onset of alcohol, tobacco, and marijuana use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Alcohol problems are influenced by both genetic and environmental factors. Evidence from twin models and measured gene-environment interaction studies has demonstrated that the importance of genetic influences changes as a function of the environment. Research has also shown that family-centered interventions may protect genetically susceptible youth from developing substance use problems. In this study, we brought large-scale gene identification findings into an intervention study to examine gene-by-intervention effects. Using genome-wide polygenic scores derived from an independent genome-wide association study of adult alcohol dependence, we examined whether an adolescent family-centered intervention would moderate the effect of genetic risk for alcohol dependence on lifetime alcohol dependence in young adulthood, approximately 15 years after the start of intervention, among European American (N = 271; 48.3% in the intervention condition) and African American individuals (N = 192; 51.6% in the intervention condition). We found that among European American individuals, the intervention moderated the association between alcohol dependence polygenic scores and lifetime alcohol dependence diagnosis in young adulthood. Among participants in the control condition, higher alcohol dependence polygenic scores were associated with a greater likelihood of receiving an alcohol dependence diagnosis; in contrast, among participants in the intervention condition, there was no association between alcohol dependence polygenic scores and alcohol dependence diagnosis. No moderation effect was found among African Americans. These results demonstrate that modifying environments of genetically vulnerable youth could reduce the likelihood of developing alcohol dependence and underscore the significance of environmentally focused prevention and intervention efforts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.