Evidence map›Paper›PMID 31175459›Full record

ArticleWorld journal of urology2020

Liquid buccal mucosa graft endoscopic urethroplasty: a validation animal study.

Kathryn A Scott, Guanqun Li, Jared Manwaring, Daniela A Nikolavsky, Yelena Fudym, Tiffany Caza, Zain Badar, Nicole Taylor, Gennady Bratslavsky, Leszek Kotula and 1 more

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Imagining the future: the five "Laws" of endourethroplasty.International urology and nephrology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A hybrid combination ofFrontiers in urology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Is regenerative medicine the future of urology?World journal of urology · 2020
    Article
  16. Review
  17. Modification of minced buccal mucosal graft endourethral urethroplasty: A pilot study.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kathryn A ScottDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Guanqun LiDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Jared ManwaringDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Daniela A NikolavskyDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Yelena FudymDepartment of Pathology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Tiffany CazaDepartment of Pathology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Zain BadarDepartment of Radiology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Nicole TaylorDepartment of Radiology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Gennady BratslavskyDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Leszek KotulaDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA.
Dmitriy NikolavskyDepartment of Urology, State University of New York Upstate Medical University, Syracuse, NY, USA. nikolavd@upstate.edu.ORCID http://orcid.org/0000-0002-8716-8740
SUNY Upstate Medical University · US

Funding

Mechanism of PIN development in Abi1/Hssh3bp1 KO mouseR01CA161018 · NCI · UPSTATE MEDICAL UNIVERSITY · PI KOTULA, LESZEK · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA161018Northeastern Section of the American Urological Association 10124
6 · The paper itself

Abstract

purposeTo validate a novel method of urethral stricture treatment using liquid buccal mucosal grafts (LBMG) to augment direct vision internal urethrotomy (DVIU) in an animal model. MATERIALS AND

methodsA rabbit stricture model was used to test this method. Strictures were induced in 26 rabbits using electroresection of urethral epithelium. The animals were randomized into two groups: Group-1, treated with DVIU and LBMG in fibrin glue, and Group-2, DVIU with fibrin glue only. LBMG was prepared by suspension of mechanically minced buccal mucosa micrografts in fibrin glue. This LBMG-fibrin glue mixture was later injected into the urethrotomies of Group-1 animals. All animals were killed at 24 weeks after repeat retrograde urethrogram (RUG) and urethroscopy by surgeon blinded to the treatment arm. Radiographic images and histological specimens were reviewed by a radiologist and a pathologist, respectively, blinded to the treatment arm. Stricture treatment was considered a success if a diameter measured on RUG increased by ≥ 50% compared to pre-treatment RUG diameter. Histological specimens were assessed for the presence of BMG engraftment.

resultsIn Group-1, 8/12(67%) animals demonstrated engraftment of LBMG, compared to none in Group-2 (p = 0.0005). 7/12(58%) in Group-1 showed radiographic resolution/improvement of strictures compared to 5/13 Group-2 rabbits (38%, p = 0.145). The median percent change for the Group-1 was 59%, compared to 41.6% for Group-2 (p = 0.29).

conclusionThis proof-of-concept study demonstrates feasibility of LBMG for endoscopic urethral stricture repairs. Further studies are needed to establish the role of this novel concept in treatment of urethral strictures.

Indexed as

AnimalsDisease Models, AnimalEndoscopyMaleMouth MucosaProspective StudiesRabbitsRandom AllocationUrethraUrethral StrictureUrologic Surgical Procedures, MaleBuccal mucosaGraftsMinimally invasive surgeryUrethral strictureUrethroplasty

Identifiers

PMID31175459
OpenAlexW2953976941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.