Evidence map›Paper›PMID 31175396›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Synthesis and in vivo evaluation of [

Songye Li, Zhengxin Cai, Wenjie Zhang, Daniel Holden, Shu-Fei Lin, Sjoerd J Finnema, Anupama Shirali, Jim Ropchan, Stephane Carre, Joel Mercier and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  3. Article
  4. Review
  5. Detection of Focal Lesions in Epilepsy with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Review
  7. New Research on Biomarkers in Alzheimer's Continuum.Reviews on recent clinical trials · 2025
    Review
  8. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  9. Assessment of cerebral drug occupancy in humans using a single PET-scan: A [European journal of nuclear medicine and molecular imaging · 2024
    Observational
  10. Article
  11. Article
  12. State of the art procedures towards reactive [EJNMMI radiopharmacy and chemistry · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Imaging of Synaptic Density in Neurodegenerative Disorders.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  18. [Nature · 2022
    Article
  19. [ACS medicinal chemistry letters · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Songye LiPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA. songye.li@yale.edu.ORCID http://orcid.org/0000-0002-6096-8756
Zhengxin CaiPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA. jason.cai@yale.edu.
Wenjie ZhangDepartment of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
Daniel HoldenPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Shu-Fei LinPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Sjoerd J FinnemaPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Anupama ShiraliPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Jim RopchanPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Stephane CarreUCB Biopharma, Braine-l'Alleud, Belgium.
Joel MercierUCB Biopharma, Braine-l'Alleud, Belgium.
Richard E CarsonPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Nabeel NabulsiPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Yiyun HuangPET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.
Yale University · USUCB Pharma (Belgium) · BESichuan University · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Synthesis and Evaluation of an 18F Labeled SV2A Ligand as a Novel Biomarker for Alzheimers DiseaseK01EB023312 · NIBIB · YALE UNIVERSITY · PI CAI, ZHENGXIN · 2017 to 2017
$171k
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS K01 EB023312
6 · The paper itself

Abstract

purposeSynaptic abnormalities have been implicated in a variety of neuropsychiatric disorders, including epilepsy, Alzheimer's disease, and schizophrenia. Hence, PET imaging of the synaptic vesicle glycoprotein 2A (SV2A) may be a valuable in vivo biomarker for neurologic and psychiatric diseases. We previously developed [

methods[

results[

conclusionWe have accomplished the first synthesis of the novel SV2A radiotracer [

Indexed as

Positron-Emission TomographyAnimalsChemistry Techniques, SyntheticFemaleFluorine RadioisotopesMacaca mulattaMaleMembrane GlycoproteinsPyridinesPyrrolidinonesRadiochemistry1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneFluorine-18Fluorine RadioisotopesMembrane GlycoproteinsPyridinesPyrrolidinonesAlzheimer’s diseaseFluorinationNonhuman primatesPETRadiotracerSV2A

Identifiers

PMID31175396
PMCPMC6810698
OpenAlexW2948776174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.