Evidence map›Paper›PMID 31175337›Full record

ReviewNature reviews. Immunology2019

Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?

Niharika A Duggal, Grace Niemiro, Stephen D R Harridge, Richard J Simpson, Janet M Lord

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 238 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed, 7 pooled it
40.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04957199 unknown statusnot on this mapstarted 2021, after this paper: background citation

Physiotherapist Awareness in the Community During the COVID-19 Pandemic Process

TypeobservationalSponsorIstanbul University - CerrahpasaRan2021 to 2021Enrolled1,550ConditionsHealthy
NCT06953648 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled126ConditionsHematopoietic Stem Cell Transplantation, Cardiorespiratory FitnessArmsHigh Intensity Interval Training
3 · Its place in the literature

Who cites it

238 citing papers in PubMed, 7 syntheses or guidelines pooled it, 451 citations in OpenAlex.

  1. Pooled it
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  5. Physical Activity during COVID-19 Lockdown in Italy: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
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  8. Trial
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  14. Article
  15. Article
  16. CD8Immunity & ageing : I & A · 2026
    Article
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  19. Review
  20. Review

178 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Niharika A DuggalMRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Grace NiemiroDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA.
Stephen D R HarridgeCentre for Human and Applied Physiological Sciences, King's College London, London, UK.
Richard J SimpsonDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA.
Janet M LordMRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. j.m.lord@bham.ac.uk.ORCID http://orcid.org/0000-0003-1030-6786
University of Arizona · USKing's College London · GBNIHR Surgical Reconstruction and Microbiology Research Centre · GBUniversity of Birmingham · GB

Funding

Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1
6 · The paper itself

Abstract

Remodelling of the immune system with age - immunosenescence - is a substantial contributor to poor health in older adults, with increasing risk of infections, cancer and chronic inflammatory disease contributing to age-related multi-morbidity. What is seldom considered when examining the immune response of an aged individual is that the immune system is profoundly influenced by physical activity. Habitual physical activity levels decline with age, with significant consequences for muscle mass and function. Skeletal muscle is a major immune regulatory organ and generates a range of proteins, termed myokines, which have anti-inflammatory and immunoprotective effects. Several studies indicate that maintaining physical activity has immune benefits in older adults, for example, it reduces the systemic inflammation associated with chronic age-related diseases. Here, we discuss how physical activity can prevent or ameliorate age-related multi-morbidity by boosting immune function, and we consider whether physical activity could improve immunotherapy outcomes in age-related conditions such as cancer.

Indexed as

ExerciseImmunosenescenceAgingCytokinesGastrointestinal MicrobiomeHumansImmune SystemKiller Cells, NaturalReceptors, Adrenergic, beta-2CytokinesReceptors, Adrenergic, beta-2

Identifiers

PMID31175337
OpenAlexW2948314199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.