Evidence map›Paper›PMID 31175296›Full record

ArticleScientific data2019

Transcriptome of dorsal root ganglia caudal to a spinal cord injury with modulated behavioral activity.

Julia H Chariker, Cynthia Gomes, Fiona Brabazon, Kathryn A Harman, Sujata Saraswat Ohri, David S K Magnuson, Scott R Whittemore, Jeffrey C Petruska, Eric C Rouchka

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Julia H CharikerDepartment of Neuroscience Training, University of Louisville, 522 East Gray Street, Louisville, Kentucky, 40202, USA.
Cynthia GomesDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Fiona BrabazonKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Kathryn A HarmanKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Sujata Saraswat OhriKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
David S K MagnusonDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Scott R WhittemoreDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Jeffrey C PetruskaDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA. j.petruska@louisville.edu.
Eric C RouchkaKentucky Biomedical Research Infrastructure Network Bioinformatics Core, 522 East Gray Street, Louisville, Kentucky, 40202, USA. eric.rouchka@louisville.edu.ORCID http://orcid.org/0000-0003-3487-6572
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Mechanisms of plasticity and repair after SCIP30GM103507 · NIGMS · UNIVERSITY OF LOUISVILLE · PI WHITTEMORE, SCOTT R · 2012 to 2015
$4.2M
Propriopsinal neuron function in normal and post-SCI locomotionR01NS112304 · NINDS · UNIVERSITY OF LOUISVILLE · PI Simon Michael Danner, David SK Magnuson · 2021 to 2026
$3.0M
Mechanisms controlling distinct modes of adult axon growthR01NS094741 · NINDS · UNIVERSITY OF LOUISVILLE · PI PETRUSKA, JEFFREY C · 2015 to 2019
$1.7M
Re-training locomotor circuitry in a rat model of spinal cord injuryR56NS052292 · NINDS · UNIVERSITY OF LOUISVILLE · PI MAGNUSON, DAVID SK · 2011 to 2011
$373k
NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P30 GM103507NINDS NIH HHS R01 NS094741NINDS NIH HHS R01 NS112304NINDS NIH HHS R56 NS052292
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a devastating clinical condition resulting in significant disabilities. Apart from local injury within the spinal cord, SCI patients develop a myriad of complications including multi-organ dysfunction. Some of the dysfunctions may be directly or indirectly related to the sensory neurons of the dorsal root ganglia (DRG), which signal to both the spinal cord and the peripheral organs. After SCI, some classes of DRG neurons exhibit sensitization and undergo axonal sprouting both peripherally and centrally. Such physiological and anatomical re-organization after SCI contributes to both adaptive and maladaptive plasticity processes, which may be modulated by activity and exercise. In this study, we collected comprehensive gene expression data in whole DRG below the levels of the injury to compare the effects of SCI with and without two different forms of exercise in rats.

Indexed as

Spinal Cord InjuriesTranscriptomeAnimalsBehavior, AnimalGanglia, SpinalNeuronal PlasticityNeurons, AfferentPhysical Conditioning, AnimalRats

Identifiers

PMID31175296
PMCPMC6555821
OpenAlexW2948187813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.