ArticleNature communications2019
Structural and functional consequences of the STAT5B
Open access · goldAbstract readVideo-Audio Media
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 83 citations in OpenAlex.
- Putative Clonal Evolution in aEJHaem · 2026Article
- Preclinical models of hepatosplenic γδ T-cell lymphoma with an activating STAT5B mutation display sensitivity to JAK inhibitor upadacitinib.HemaSphere · 2026Article
- Real-time visualization of STAT activation in live cells using genetically encoded biosensors.Nature chemical biology · 2026Article
- Searching for Monogenic Autoimmune Etiology in Patients With Type 1 Diabetes Onset Before 30 Months of Age.The Journal of clinical endocrinology and metabolism · 2025Article
- Ultrahigh-Throughput Virtual Screening Strategies against PPI Targets: A Case Study of STAT Inhibitors.Journal of chemical information and modeling · 2025Article
- STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.Life science alliance · 2025Article
- Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia.Leukemia · 2025Article
- Malignant JAK-signaling: at the interface of inflammation and malignant transformation.Leukemia · 2025Review
- The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain.Protein science : a publication of the Protein Society · 2025Article
- Recurrent Missense Driver STAT5BAnti-cancer agents in medicinal chemistry · 2025Article
- Eosinophilia withTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma.HemaSphere · 2024Article
- Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms.Nature immunology · 2024Article
- Article
- Unveiling myeloid transformation: T-LGLL with eosinophilia masking myeloid-associated STAT5B mutation culminating in AML.British journal of haematology · 2024Article
- Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.The Journal of clinical investigation · 2024Article
- Signal Transducer and Activator of Transcription Proteins at the Nexus of Immunodeficiency, Autoimmunity and Cancer.Biomedicines · 2023Review
- The potential effect and mechanism of Saikosaponin A against gastric cancer.BMC complementary medicine and therapies · 2023Article
- STAT5b gain-of-function disease in a child with mycobacterial osteomyelitis of the skull: rare presentation of an emerging disease entity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 4 institutions in 3 countries.
Elvin D de AraujoDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.ORCID http://orcid.org/0000-0003-0716-2830
Fettah ErdoganDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.ORCID http://orcid.org/0000-0002-6968-4821
Heidi A NeubauerInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Deniz Meneksedag-ErolDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.ORCID http://orcid.org/0000-0002-7765-3304
Pimyupa ManaswiyoungkulDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Mohammad S EramDalriada Drug Discovery, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Hyuk-Soo SeoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0003-0646-2102
Abdul K QadreeDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.
Johan IsraelianDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.ORCID http://orcid.org/0000-0001-8042-461X
Anna OrlovaInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Tobias SuskeInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Ha T T PhamInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.ORCID http://orcid.org/0000-0001-8484-470X
Auke BoersmaInstitute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Simone TangermannUnit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.
Lukas KennerLudwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.
Thomas RülickeInstitute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.ORCID http://orcid.org/0000-0002-2121-9496
Aiping DongStructural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.
Manimekalai RavichandranStructural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.
Peter J BrownStructural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.ORCID http://orcid.org/0000-0002-8454-0367
Gerald F AudetteDepartment of Chemistry, York University, 327C Life Sciences Building, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.ORCID http://orcid.org/0000-0002-5695-9830
Sarah RauscherDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.ORCID http://orcid.org/0000-0001-9860-3237
Sirano Dhe-PaganonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.
Richard MorigglInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.ORCID http://orcid.org/0000-0003-0918-9463
Patrick T GunningDepartment of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada. patrick.gunning@utoronto.ca.
University of Toronto · CAUniversity of Veterinary Medicine Vienna · ATHarvard University · USYork University · CA
Funding
Austrian Science Fund FWF I 4157Austrian Science Fund FWF I 4218
Abstract
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B
Indexed as
Intraepithelial LymphocytesMutationAnimalsHematologic NeoplasmsHumansLeukemia, T-CellLymphoma, T-CellMiceMice, TransgenicMolecular Docking Simulationsrc Homology DomainsSTAT5 Transcription FactorSTAT5B protein, humanSTAT5 Transcription Factor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.