ArticleTranslational psychiatry2019
Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Variability of glucose, insulin, and lipid disturbances in first-episode psychosis: a meta-analysis.Psychological medicine · 2023Pooled it
- Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients.World journal of psychiatry · 2026Trial
- Investigating the causal associations between neuroticism, schizophrenia, and cardiovascular diseases using Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2026Article
- Effects of Schizophrenia, Bipolar Disorder, and Depression on Cardiopulmonary and Abdominal Organ Structure.Biological psychiatry global open science · 2026Article
- Psychosis as a multisystem disorder of aberrant aging.npj aging · 2026Review
- Comorbidity patterns and immune-metabolic differences in patients with acute-episode of schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2025Article
- Pharmacological and psychological approaches to insomnia treatment in cardiac patients: a narrative literature review.Frontiers in psychiatry · 2025Review
- Detecting outliers in case-control cohorts for improving deep learning networks on Schizophrenia prediction.Journal of integrative bioinformatics · 2024Article
- RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation.Schizophrenia (Heidelberg, Germany) · 2024Article
- Severe mental illness: cardiovascular risk assessment and management.European heart journal · 2024Article
- Detrimental Impact of Comorbid Mental Disorders in Chronic Thromboembolic Pulmonary Hypertension - A Retrospective Observational Study.Circulation reports · 2024Article
- Psychological wellbeing and treatment adherence among cardio-renal syndrome patients in Yemen: a cross section study.Frontiers in medicine · 2024Article
- Abnormal blood lipid and electrocardiogram characteristics in common mental disorders.BMC psychiatry · 2023Article
- Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study.Cardiovascular diabetology · 2023Article
- CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity.Signal transduction and targeted therapy · 2022Article
- A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study.Schizophrenia bulletin · 2022Article
- Schizophrenia Hypothesis: Autonomic Nervous System Dysregulation of Fetal and Adult Immune Tolerance.Frontiers in systems neuroscience · 2022Article
- Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.Translational psychiatry · 2021Article
- Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Cardiovascular disease (CVD) is a major cause of excess mortality in schizophrenia. Preclinical evidence shows antipsychotics can cause myocardial fibrosis and myocardial inflammation in murine models, but it is not known if this is the case in patients. We therefore set out to determine if there is evidence of cardiac fibrosis and/or inflammation using cardiac MRI in medicated patients with schizophrenia compared with matched healthy controls. Thirty-one participants (14 patients and 17 controls) underwent cardiac MRI assessing myocardial markers of fibrosis/inflammation, indexed by native myocardial T1 time, and cardiac structure (left ventricular (LV) mass) and function (left/right ventricular end-diastolic and end-systolic volumes, stroke volumes, and ejection fractions). Participants were physically fit, and matched for age, gender, smoking, blood pressure, BMI, HbA1c, ethnicity, and physical activity. Compared with controls, native myocardial T1 was significantly longer in patients with schizophrenia (effect size, d = 0.89; p = 0.02). Patients had significantly lower LV mass, and lower left/right ventricular end-diastolic and stroke volumes (effect sizes, d = 0.86-1.08; all p-values < 0.05). There were no significant differences in left/right end-systolic volumes and ejection fractions between groups (p > 0.05). These results suggest an early diffuse fibro-inflammatory myocardial process in patients that is independent of established CVD-risk factors and could contribute to the excess cardiovascular mortality associated with schizophrenia. Future studies are required to determine if this is due to antipsychotic treatment or is intrinsic to schizophrenia.
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Registered trials
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