Evidence map›Paper›PMID 31175125›Full record

ArticleArchives of disease in childhood2019

Parents' prioritised outcomes for trials investigating treatments for paediatric severe infection: a qualitative synthesis.

Kerry Woolfall, Caitlin O'Hara, Elizabeth Deja, Ruth Canter, Imran Khan, Paul Mouncey, Anjali Carter, Nicola Jones, Jason Watkins, Mark David Lyttle and 9 more

Abstract read
In one paragraph

Article in Archives of disease in childhood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Timing of Stoma Closure in Neonates: the ToSCiN mixed-methods study.Health technology assessment (Winchester, England) · 2024
    Observational
  7. Article
  8. Article
  9. Priorities for paediatric critical care research: a modified Delphi study by the Australian and New Zealand Intensive Care Society Paediatric Study Group.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kerry WoolfallHealth Services Research, University of Liverpool, Liverpool, UK.
Caitlin O'HaraHealth Services Research, University of Liverpool, Liverpool, UK.
Elizabeth DejaHealth Services Research, University of Liverpool, Liverpool, UK.
Ruth CanterIntensive Care National Audit & Research Centre (ICNARC), London, UK.
Imran KhanCentre of Primary Care and Public Health, Queen Mary University of London, London, UK.
Paul MounceyIntensive Care National Audit & Research Centre (ICNARC), London, UK.
Anjali CarterPatient partner, London, UK.
Nicola JonesPatient partner, London, UK.
Jason WatkinsPatient partner, London, UK.
Mark David LyttleEmergency Department, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Lyvonne TumeEmergency Department, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Rachel AgbekoPaediatric Intensive Care, Great North Children's Hospital, Newcastle upon Tyne, UK.ORCID 0000-0001-8931-6869
Shane M TibbyDepartment of Paediatric Intensive Care, Evelina Childrens Hospital, Guys St Thomas NHS Foundation Trust, London, UK.ORCID 0000-0001-7774-8656
John PappachanPaediatric Intensive Care, Southampton Children's Hospital, Southampton, UK.
Kent ThorburnPaediatric Intensive Care, Royal Liverpool Childrens Hospital Alder Hey, Liverpool, UK.
Kathryn M RowanIntensive Care National Audit & Research Centre (ICNARC), London, UK.
Mark John PetersPaediatric Intensive Care, Great Ormond St Hospital NHS Trust, London, UK.
David InwaldPaediatric Intensive Care Unit, Imperial College Healthcare NHS Trust, London, UK.
PERUKI (Paediatric Emergency Research in the UK and Ireland) and PICS (Paediatric Intensive Care Society)

Funding

Department of Health HTA/15/44/01
6 · The paper itself

Abstract

objectiveTo identify parents' prioritised outcomes by combining qualitative findings from two trial feasibility studies of interventions for paediatric suspected severe infection.

designQualitative synthesis combining parent interview data from the Fluids in Shock (FiSh) and Fever feasibility studies. Parents had experience of their child being admitted to a UK emergency department or intensive care unit with a suspected infection.

participantsn=: 85 parents. FiSh study: n=41 parents, 37 mothers, 4 fathers, 7 were bereaved. Fever study: n=44 parents, 33 mothers, 11 fathers, 7 were bereaved.

resultsIn addition to survival, parents prioritised short-term outcomes including: organ and physiological functioning (eg, heart rate, breathing rate and temperature); their child looking and/or behaving more like their normal self; and length of time on treatments or mechanical support. Longer term prioritised outcomes included effects of illness on child health and development. We found that parents' prioritisation of outcomes was influenced by their experience of their child's illness, survival and the point at which they are asked about outcomes of importance in the course of their child's illness.

conclusionsFindings provide insight into parent prioritised outcomes to inform the design of future trials investigating treatments for paediatric suspected or proven severe infection as well as core outcome set development work.

Indexed as

Intensive Care Units, PediatricBacterial InfectionsChildChild, PreschoolCritical CareEmotionsFeasibility StudiesFemaleHumansMaleOutcome Assessment, Health CareParentsProfessional-Family RelationsQualitative ResearchStress, PsychologicalVirus Diseasesclinical trialsoutcomes researchpaediatricsparentssevere infection

Identifiers

PMID31175125
PMCPMC6837249

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.