Evidence map›Paper›PMID 31175121›Full record

ArticleDevelopment (Cambridge, England)2019

Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.

Laura Andrés-Delgado, Alexander Ernst, María Galardi-Castilla, David Bazaga, Marina Peralta, Juliane Münch, Juan M González-Rosa, Inês Marques, Federico Tessadori, José Luis de la Pompa and 2 more

Open access · hybridAbstract readVideo-Audio Media
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium.Developmental dynamics : an official publication of the American Association of Anatomists · 2020
    Article
  10. Article
  11. Epicardium in Heart Development.Cold Spring Harbor perspectives in biology · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 6 countries.

Laura Andrés-DelgadoDevelopment of the Epicardium and its Role During Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Alexander ErnstInstitute of Anatomy, University of Bern, 3000 Bern 9, Switzerland.ORCID 0000-0002-9979-8002
María Galardi-CastillaDevelopment of the Epicardium and its Role During Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.ORCID 0000-0003-2455-6671
David BazagaDevelopment of the Epicardium and its Role During Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.ORCID 0000-0002-5758-8402
Marina PeraltaInstitut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France.
Juliane MünchIntercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Juan M González-RosaDevelopment of the Epicardium and its Role During Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Inês MarquesInstitute of Anatomy, University of Bern, 3000 Bern 9, Switzerland.
Federico TessadoriHubrecht Institute-KNAW and UMC Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.
José Luis de la PompaIntercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain.ORCID 0000-0001-6761-7265
Julien VermotInstitut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France.ORCID 0000-0002-8924-732X
Nadia MercaderDevelopment of the Epicardium and its Role During Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain nadia.mercader@ana.unibe.ch.ORCID 0000-0002-0905-6399
Spanish National Centre for Cardiovascular Research · ESUniversity of Bern · CHHarvard University · USInstitut de génétique et de biologie moléculaire et cellulaire · FRUniversity Medical Center Utrecht · NLUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative

Indexed as

Cell MovementActinsAnimalsAnimals, Genetically ModifiedBody PatterningBone Morphogenetic ProteinsCarrier ProteinsEmbryo, NonmammalianHeartMyocardiumOrganogenesisPericardiumSignal TransductionStem CellsZebrafishZebrafish ProteinsActinsBone Morphogenetic ProteinsCarrier Proteinspard3ab protein, zebrafishZebrafish ProteinsActomyosinBmpCell extrusionHeart developmentProepicardiumZebrafish

Identifiers

PMID31175121
PMCPMC6633599
OpenAlexW2953439985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.