ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019
Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
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- Vibroacoustic signatures: proof of concept for simple material characterization during needle interventions.International journal of computer assisted radiology and surgery · 2025Article
- Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary FibrosisAmerican journal of respiratory and critical care medicine · 2024Article
- Effects of Cochlear Implantation and Steroids on the Aging Guinea Pig Cochlea.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Insights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach.Scientific reports · 2024Article
- Assessing Lung Fibrosis with ML-Assisted Minimally Invasive OCT Imaging.Diagnostics (Basel, Switzerland) · 2024Article
- 2023 American Thoracic Society BEAR Cage Winning Proposal. Endobronchial Optical Coherence Tomography: A Novel Imaging Technique for Early Microscopic Diagnosis and Monitoring of Interstitial Lung Disease.American journal of respiratory and critical care medicine · 2024Article
- Polarization-sensitive optical coherence tomography for renal tumor detection inOptics and lasers in engineering · 2024Article
- Optical anisotropy composition of benign and malignant prostate tissues revealed by Mueller-matrix imaging.Biomedical optics express · 2022Article
- Polarization-Sensitive Endobronchial Optical Coherence Tomography for Microscopic Imaging of Fibrosis in Interstitial Lung Disease.American journal of respiratory and critical care medicine · 2022Article
- En-face polarization-sensitive optical coherence tomography to characterize early-stage esophageal cancer and determine tumor margin.Biomedical optics express · 2022Article
- Differences in the characteristics and pulmonary toxicity of nano- and micron-sized respirable coal dust.Respiratory research · 2022Article
- Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy.Nature communications · 2022Article
- Reply to KalverdaAmerican journal of respiratory and critical care medicine · 2022Article
- Research progress on the application of optical coherence tomography in the field of oncology.Frontiers in oncology · 2022Review
- Morphologic and Microvascular Differences Between Macular Neovascularization With and Without Subretinal Fibrosis.Translational vision science & technology · 2021Article
- Diagnostic Accuracy of Endobronchial Optical Coherence Tomography for the Microscopic Diagnosis of Usual Interstitial Pneumonia.American journal of respiratory and critical care medicine · 2021Article
- Polarization-sensitive optical coherence tomography in end-stage lung diseases: an ex vivo pilot study.Biomedical optics express · 2021Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeWith recent advancements in personalized medicine, biopsies must contain sufficient tumor for histologic diagnosis and molecular testing. However, inadvertent biopsy of tumor-associated fibrosis compromises tumor yield, resulting in delayed diagnoses and/or repeat procedures when additional tumor is needed. The ability to differentiate tumor from fibrosis intraprocedurally during biopsy could significantly increase tumor yield. Polarization-sensitive optical coherence tomography (PS-OCT) is an imaging modality that is endoscope- and/or needle-compatible, and provides large volumetric views of tissue microstructure with high resolution (∼10 μm) while simultaneously measuring birefringence of organized tissues such as collagen. We aim to determine whether PS-OCT can accurately detect and distinguish tumor-associated fibrosis from tumor. EXPERIMENTAL
designPS-OCT was obtained
resultsThere was a strong positive correlation between PS-OCT measurement of birefringent fibrosis and total collagen content by PSR (
conclusionsPS-OCT enables accurate fibrosis detection and can distinguish tumor regions with low fibrosis. PS-OCT has significant potential for clinical impact, as the ability to differentiate tumor from fibrosis could be used to guide intraprocedural tissue sampling
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