ReviewTrends in cognitive sciences2019
Neural Dedifferentiation in the Aging Brain.
Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
188 citing papers in PubMed, 4 syntheses or guidelines pooled it, 368 citations in OpenAlex.
- A systematic review of global signal topography in aging, neuropsychiatric disorders, and cognitive task performance.Brain imaging and behavior · 2026Pooled it
- A meta-analysis of cognitive flexibility in aging: Perspective from functional network and lateralization.Human brain mapping · 2024Pooled it
- Determinants of academic achievement among higher education student found in low resource setting, A systematic review.PloS one · 2023Pooled it
- Magnetic resonance elastography of the ageing brain in normal and demented populations: A systematic review.Human brain mapping · 2022Pooled it
- Effects of mindfulness training on sustained attention and mind-wandering in older adults: results from the HealthyAgers randomized controlled trial.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Trial
- Intact embodiment during perspective-taking in older adults is not affected by focal tDCS.GeroScience · 2025Trial
- Increased segregation of structural brain networks underpins enhanced broad cognitive abilities of cognitive training.Human brain mapping · 2021Trial
- Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging.GeroScience · 2026Article
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- Effects of age on memory-related category-selective connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Feasibility of Gamified EEG Neurofeedback Combined with Adaptive Working-Memory Training in Older Adults: A Pilot Study.Brain sciences · 2026Article
- Electrophysiological correlates of cognitive reserve in healthy older adults at different cognitive states.Cognitive, affective & behavioral neuroscience · 2026Article
- Cognitive network plasticity across divergent aging trajectories: an exploratory graph-theoretic study.GeroScience · 2026Article
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk.GeroScience · 2026Article
- Widening participation in cognitive neuroscience: a mixed-methods study of age-related motivators, barriers and attitudes towards imaging methods.BMC medical research methodology · 2026Article
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Age-related differences in spatial memory occur alongside reduced visual fMRI BOLD but preserved viewpoint-specific scene representations.bioRxiv : the preprint server for biology · 2026Article
- Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Kernel-Transformed Functional Connectivity Entropy Reveals Network Dedifferentiation in Bipolar Disorder.Brain sciences · 2026Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Many cognitive abilities decline with age even in the absence of detectable pathology. Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms of neural selectivity, may contribute to this decline. We review here work exploring the relationship between neural dedifferentiation, cognition, and age. Compelling evidence for age effects on neural selectivity comes from both non-human animal and human research. However, current data suggest that age does not moderate the observed relationships between neural dedifferentiation and cognitive performance. We propose that functionally significant variance in measures of neural dedifferentiation reflects both age-dependent and age-independent factors. We further propose that the effects of age on neural dedifferentiation do not exclusively reflect detrimental consequences of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.