Evidence map›Paper›PMID 31174838›Full record

ArticleTrends in cancer2019

Solid Stress in Brain Tumors.

Daniele M Gilkes, Denis Wirtz

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daniele M GilkesSidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Physical Sciences in Oncology Center, and Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: dgilkes1@jhu.edu.
Denis WirtzSidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, Physical Sciences in Oncology Center, and Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · USSidney Kimmel Comprehensive Cancer Center · US

Funding

TRANS NETWORK PROJECTSU54CA143868 · NCI · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS · 2009 to 2013
$13.7M
The role of the hypoxic ECM on integrin-induced breast cancer metastasisR00CA181352 · NCI · JOHNS HOPKINS UNIVERSITY · PI GILKES, DANIELE MARIE · 2015 to 2017
$747k
The role of the hypoxic ECM on integrin-induced breast cancer metastasisK99CA181352 · NCI · JOHNS HOPKINS UNIVERSITY · PI GILKES, DANIELE MARIE · 2014 to 2015
$181k
NCI NIH HHS K99 CA181352NCI NIH HHS R00 CA181352NCI NIH HHS U54 CA143868
6 · The paper itself

Abstract

A solid brain tumor mass places compressive forces on adjacent normal brain tissue, and clinically presents as impaired motor performance in cancer patients, ultimately limiting their quality of life. In a recent article by Jain and colleagues (Nat. Biomed. Eng. 2019;3:230-245), the biological consequences of mechanical forces imparted by a growing tumor mass are explored in both mouse models and human brain tumors, revealing a novel opportunity for therapeutic intervention.

Indexed as

Brain NeoplasmsLithiumAnimalsBrainDisease Models, AnimalHumansMiceQuality of LifeLithium

Identifiers

PMID31174838
OpenAlexW2940058040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.