ArticleClinical & experimental metastasis
Interferon-mediated enhancement of metastasis. Are MHC antigens involved?
Article in Clinical & experimental metastasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Clinical Implications of UpregulatedDiseases (Basel, Switzerland) · 2025Article
- IFN-γ and CD38 in Hyperprogressive Cancer Development.Cancers · 2021Review
- The Interactions Between Cancer Stem Cells and the Innate Interferon Signaling Pathway.Frontiers in immunology · 2020Review
- Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.PloS one · 2013Article
- Equus caballus major histocompatibility complex class I is an entry receptor for equine herpesvirus type 1.Journal of virology · 2010Article
- In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.The Journal of experimental medicine · 1994Article
- Selection for enhanced adhesion to microvessel endothelial cells or resistance to interferon-gamma modulates the metastatic potential of murine RAW117 large-cell lymphoma cells.Clinical & experimental metastasis · 1993Article
- Suppression by interferon-gamma of tumor cell-induced increase in mesothelial permeability.Clinical & experimental metastasis · 1992Article
- Role of major histocompatibility complex class-I molecules in tumor rejection. New insights from studies with synthetic peptides and transgenic mice.Immunologic research · 1990Review
- A detailed study of the effects of in vitro interferon treatment on the growth of two variants of the B16 mouse melanoma in the lungs: evidence for non-specific effects.Clinical & experimental metastasisArticle
- Radiation enhancement of metastasis: a review.Clinical & experimental metastasisReview
- Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.Clinical & experimental metastasisArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between major histocompatibility complex (MHC) antigens and metastasis was investigated on B16 melanoma variants. B16 cell lines express low amounts of murine MHC (H-2) antigens. A high expression can be induced in line B16-A by in vitro treatment with immune interferon (IFN-gamma) or by in vivo transplant in allogeneic mice. The increase of H-2 antigens correlated with an enhancement of lung colonization in young syngeneic mice. The higher metastatic capacity of B16-A cells with induced high levels of H-2 antigens was observed also in adult mice and in young mice pretreated with cyclophosphamide. These results were confirmed investigating the behaviour of a mutant B16 clone (B78H1) which was selectively resistant to the H-2-inducing action of IFN-gamma: lung colonization ability was not increased by IFN pretreatment. The study of variants derived from individual B16-A lung colonies revealed a wide range of H-2 levels. Variants with a low expression had a low colonization ability; one out of two variants with a high H-2 expression also was poorly colonizing. IFN-gamma-mediated H-2 expression appeared to act as an enhancer, rather than a determinant of B16 metastatic capacity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.