ArticleCancer imaging : the official publication of the International Cancer Imaging Society2019
Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Prognostic value of quantitative multiparametric magnetic resonance imaging parameters and histopathologic features for disease-free survival in locally advanced non-mucinous rectal adenocarcinoma.Abdominal radiology (New York) · 2026Article
- Quantitative MRI for World Health Organisation/International Society of Urological Pathology Grading of Renal Cell Carcinoma: a systematic review and diagnostic meta-analysis.European radiology · 2026Article
- Quantitative T2 mapping of junctional zone alterations in endometrial fibrosis: comparison with diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2026Article
- Clinical Utility of Quantitative MRI Parameters for Differentiation of Renal Tumor Subtypes and Who Grades: A Multiparametric Approach with Internal Cortical Reference.Journal of clinical medicine · 2026Article
- Noninvasive Differentiation of Indolent from Aggressive Renal Neoplasms with MR Fingerprinting Combined with Diffusion/Perfusion MRI.Radiology · 2026Article
- Exploration of prognostic prediction models for renal cell carcinoma using diffusion relaxation correlation spectroscopic imaging.BMC medical imaging · 2026Article
- Accelerating 2D Kidney Magnetic Resonance Fingerprinting Using Deep Learning Based Tissue Quantification.Journal of magnetic resonance imaging : JMRI · 2026Article
- Assessing the Impact of Imaging Parameters on MRI Measurement of Kidney TJournal of magnetic resonance imaging : JMRI · 2026Article
- Technical Optimization of SyntheticMR for the Head and Neck on a 3T MR-Simulator and 1.5T MR-Linac: A Prospective R-IDEAL Stage 2a Technology Innovation Report.medRxiv : the preprint server for health sciences · 2025Article
- Feasibility and Reproducibility of T2 Mapping Compared with Diffusion-Weighted Imaging in Solid Renal Masses.Bioengineering (Basel, Switzerland) · 2024Article
- High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades.European radiology experimental · 2024Article
- Multiparametric MRI for characterization of the tumour microenvironment.Nature reviews. Clinical oncology · 2024Review
- Predicting the status of lymphovascular space invasion using quantitative parameters from synthetic MRI in cervical squamous cell carcinoma without lymphatic metastasis.Frontiers in oncology · 2024Article
- T1 and T2 mapping for identifying malignant lymph nodes in head and neck squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Radiomic Analysis of Quantitative T2 Mapping and Conventional MRI in Predicting Histologic Grade of Bladder Cancer.Journal of clinical medicine · 2023Article
- Feasibility of accelerated T2 mapping for the preoperative assessment of endometrial carcinoma.Frontiers in oncology · 2023Article
- Cancellation of streak artifacts in radial abdominal imaging using interference null space projection.Magnetic resonance in medicine · 2022Article
- Low-rank inversion reconstruction for through-plane accelerated radial MR fingerprinting applied to relaxometry at 0.35 T.Magnetic resonance in medicine · 2022Article
- Diagnostic performance of synthetic magnetic resonance imaging in the prognostic evaluation of rectal cancer.Quantitative imaging in medicine and surgery · 2022Article
- Abdominal T2-Weighted Imaging and T2 Mapping Using a Variable Flip Angle Radial Turbo Spin-Echo Technique.Journal of magnetic resonance imaging : JMRI · 2022Article
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Abstract
backgroundCorrect staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial resection with postoperative tumor grading currently remain the methods of choice for the classification of cRCC, non-invasive preoperative alternatives to differentiate lower grade from higher grade cRCC would be beneficial.
methodsThis institutional-review-board approved cross-sectional study included twenty-seven patients (8 women, mean age ± SD, 61.3 ± 14.2) with histopathologically confirmed cRCC, graded according to the International Society of Urological Pathology (ISUP). A native, balanced steady-state free precession T2 mapping sequence (TrueFISP) was performed at 1.5 T. Quantitative T2 values were measured with circular 2D ROIs in the solid tumor portion and also in the normal renal parenchyma (cortex and medulla). To estimate the optimal cut-off T2 value for identifying lower grade cRCC, a Receiver Operating Characteristic Curve (ROC) analysis was performed and sensitivity and specificity were calculated. Students' t-tests were used to evaluate the differences in mean values for continuous variables, while intergroup differences were tested for significance with two-tailed Mann-Whitney-U tests.
resultsThere were significant differences between the T2 values for lower grade (ISUP 1-2) and higher grade (ISUP 3-4) cRCC (p < 0.001), with higher T2 values for lower grade cRCC compared to higher grade cRCC. The sensitivity and specificity for the differentiation of lower grade from higher grade tumors were 83.3% (95% CI: 0.59-0.96) and 88.9% (95% CI: 0.52-1.00), respectively, using a threshold value of ≥110 ms. Intraobserver/interobserver agreement for T2 measurements was excellent/substantial.
conclusionsNative T2 mapping based on a balanced steady-state free precession MR sequence might support an image-based distinction between lower and higher grade cRCC in a two-tier-system and could be a helpful addition to multiparametric imaging.
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