ArticleBMC endocrine disorders2019
Thyroid function, body mass index, and metabolic risk markers in euthyroid adults: a cohort study.
Article in BMC endocrine disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Immune checkpoint inhibitors-related thyroid dysfunction: influencing factor analysis, prediction model development, and management strategy proposal.Cancer immunology, immunotherapy : CII · 2024Pooled it
- The Influence of Reducing Diets on Changes in Thyroid Parameters in Women Suffering from Obesity and Hashimoto's Disease.Nutrients · 2021Trial
- Article
- Nonlinear Association Between THs, TSH, and HbA1c in Patients With Type 2 Diabetes Mellitus: A Retrospective Study.Journal of diabetes · 2026Article
- Association between cardiometabolic index and thyroid function: insights from NHANES.Hormones (Athens, Greece) · 2026Article
- The association between maternal FT3/FT4 ratio in early pregnancy and adverse neonatal outcomes: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Prevalence and correlates of overweight and obesity in patients with major depression accompanied by abnormal TSH levels.BMC psychiatry · 2025Article
- Gender Differences in Prevalence and Clinical Correlates of Initial-Treatment and Drug-Naïve Bipolar Disorder Patients With Metabolic Syndrome: A Cross-Sectional Study.Alpha psychiatry · 2025Article
- Associations of free triiodothyronine and thyroxine with blood pressure in Chinese coronary artery disease adults.BMC cardiovascular disorders · 2025Article
- The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Review
- Body roundness index, thyroid hormones, and threshold effects in US adults: a cross-sectional study from NHANES.Frontiers in nutrition · 2025Article
- Mitochondrial function is enhanced by thyroid hormones during zebra finch development.Royal Society open science · 2024Article
- Exploring the oral-gut microbiota during thyroid cancer: Factors affecting the thyroid functions and cancer development.Food science & nutrition · 2023Review
- Normative range of various serum hormonal parameters among Indian women of reproductive age: ICMR-PCOS task force study outcome.The Lancet regional health. Southeast Asia · 2023Article
- High free triiodothyronine, and free-triiodothyronine-to-free-thyroxine ratio are associated with metabolic syndrome in a euthyroid employee population: the Zhejiang Zhenhai study.Endocrine connections · 2023Article
- Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice.Thyroid research · 2023Review
- Type 2 Diabetes Mellitus Coincident with Clinical and Subclinical Thyroid Dysfunctions Results in Dysregulation of Circulating Chemerin, Resistin and Visfatin.Biomedicines · 2023Article
- Circulating free T3 associates longitudinally with cardio-metabolic risk factors in euthyroid children with higher TSH.Frontiers in endocrinology · 2023Article
- Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study.Lipids in health and disease · 2022Article
- Exploring associations of anthropometric parameters and serum triglycerides with serum thyroid hormones in young women.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, the relationship between thyroid stimulating hormone (TSH) and obesity has been widely discussed. However, it is unclear how thyroid hormone concentrations relate to body weight and its impact on metabolic risk markers. This study aimed to assess how thyroid function is linked to underweight, overweight, or obesity, and metabolic risk markers in adults.
methodsA total of 16,975 subjects, aged 18-80 years, who attended the Health Management Center of Tongji Hospital, Wuhan, China were enrolled in this study. Anthropometric and laboratory data were collected and analyzed.
resultsSerum free triiodothyronine (fT3) and fT3/free thyroxine (fT4) ratio (fT3/fT4) were positively associated with body mass index (BMI) (P < 0.001), while there was a negative relationship between fT4 and BMI (P < 0.001) according to multivariable regression analysis adjusted for age and sex. Associations between thyroid hormone concentrations and markers of blood pressure, and lipid and glucose metabolism were identified after adjustment for age, sex, and BMI, with TSH being negatively associated with fasting blood glucose (FBG). fT3 was positively associated with systolic blood pressure and low-density lipoprotein-cholesterol, while fT4 was positively associated with diastolic blood pressure, FBG, and high-density lipoprotein-cholesterol (HDL-C), and negatively associated with hemoglobin A1c (HbA1c) and triglyceride. Finally, fT3/fT4 was positively associated with HbA1c and triglyceride, and negatively associated with HDL-C.
conclusionsOverweight or obese participants had a high serum concentration of fT3, high fT3/fT4 ratio, and a low concentration of fT4. Underweight participants had high concentrations of fT4 and low concentrations of fT3. Thus, relationships between thyroid hormones and metabolic risk markers were identified which suggest that thyroid function might be one factor that influences body weight and the co-morbidities of obesity.
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