Evidence map›Paper›PMID 31174404›Full record

ReviewCells2019

Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology.

Patrick C Bailey, Stuart S Martin

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cancer Stem Cells (CD44Journal of obstetrics and gynaecology of India · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Patrick C BaileyMarlene and Stewart Greenebaum Comprehensive Cancer Center, School of Medicine (UMGCCC), University of Maryland, Baltimore, MD 21201, USA. pcbailey@umaryland.edu.
Stuart S MartinMarlene and Stewart Greenebaum Comprehensive Cancer Center, School of Medicine (UMGCCC), University of Maryland, Baltimore, MD 21201, USA. ssmartin@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Tubulin microtentacles in detached mammary epithelial cellsR01CA124704 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTIN, STUART S · 2007 to 2025
$5.7M
Targeting microtubule stabilization to reduce breast tumor metastasisR01CA154624 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTIN, STUART S · 2012 to 2023
$3.4M
Rapid analysis of patient tumor cell drug responses to reduce metastatic riskI01BX002746 · VA · BALTIMORE VA MEDICAL CENTER · PI MARTIN, STUART S · 2019 to 2024
–
BLRD VA I01 BX002746NCI NIH HHS R01 CA124704NCI NIH HHS R01 CA154624
6 · The paper itself

Abstract

Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertise the presence of metastasis before clinical presentation, enabling the early detection of relapse. Importantly, emerging evidence is indicating that cancer treatments can actually increase the incidence of CTCs and metastasis in pre-clinical models. Subsequently, the study of CTCs, their biology and function are of vital importance. Emerging technologies for the capture of CTC/CTMs and CTMat are elucidating vitally important biological and functional information that can lead to important alterations in how therapies are administered. This paves the way for the development of a "liquid biopsy" where treatment decisions can be informed by information gleaned from tumor cells and tumor cell debris in the blood.

Indexed as

Epithelial Cell Adhesion MoleculeEpithelial-Mesenchymal TransitionErb-b2 Receptor Tyrosine KinasesHumansImmunomagnetic SeparationNeoplasm Recurrence, LocalNeoplasmsNeoplastic Cells, CirculatingEpithelial Cell Adhesion MoleculeERBB2 protein, humanErb-b2 Receptor Tyrosine Kinasescirculating tumor cellsCTCCTC biologyCTC capture technologyCTMCTMatliquid biopsy

Identifiers

PMID31174404
PMCPMC6627072
OpenAlexW2945891183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.