Evidence map›Paper›PMID 31174276›Full record

ArticleJournal of clinical medicine2019

Effects of Insulin on Porcine Neonatal Sertoli Cell Responsiveness to FSH In Vitro.

Rossella Cannarella, Iva Arato, Rosita A Condorelli, Laura M Mongioì, Cinzia Lilli, Catia Bellucci, Sandro La Vignera, Giovanni Luca, Francesca Mancuso, Aldo E Calogero

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Commentary: Molecular Mechanisms of Action of FSH.Frontiers in endocrinology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. roxcannarella@gmail.com.ORCID 0000-0003-4599-8487
Iva AratoDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. iva.arato@libero.it.
Rosita A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. rosita.condorelli@unict.it.ORCID 0000-0002-5217-9343
Laura M MongioìDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. lauramongioi@hotmail.it.ORCID 0000-0003-2341-0996
Cinzia LilliDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. cinzia.lilli@unipg.it.
Catia BellucciDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. catia.bellucci@unipg.it.
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. sandrolavignera@unict.it.ORCID 0000-0002-7113-2372
Giovanni LucaDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. giovanni.luca@unipg.it.
Francesca MancusoDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. francesca.mancuso@unipg.it.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. acaloger@unict.it.ORCID 0000-0001-6950-335X
University of Catania · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is ongoing debate as to whether the decline of sperm production in recent times may be related to a parallel increase in the rate of obesity and diabetes. Lower anti-Müllerian hormone (AMH) and inhibin B secretion have been observed in young hyperinsulinemic patients compared to healthy controls, suggesting a Sertoli cell (SC) dysfunction. The pathophysiological mechanisms underlying SC dysfunction in these patients are poorly understood. To the best of our knowledge, no evidence is available on the effects of insulin on SC function. Therefore, this study was undertaken to assess the effects of insulin on basal and follicle-stimulating hormone (FSH)-stimulated SC function in vitro. To accomplish this, we evaluated the expression of

Indexed as

AMHFSHinhibin BinsulinSertoli cells

Identifiers

PMID31174276
PMCPMC6617126
OpenAlexW2948463241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.