ReviewAntioxidants (Basel, Switzerland)2019
Molecular Mechanisms of Zinc as a Pro-Antioxidant Mediator: Clinical Therapeutic Implications.
Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 3 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Serum Zinc Level and Efficacy of Zinc Therapy in Cutaneous Leishmaniasis: a Systematic Review and Meta-analysis.Biological trace element research · 2024Pooled it
- Evaluation of nutrients in bread: a systematic review.Journal of health, population, and nutrition · 2022Pooled it
- Zinc as a complementary treatment for cancer patients: a systematic review.Clinical and experimental medicine · 2021Pooled it
- Adjuvant therapy with zinc supplementation; anti-inflammatory and anti-oxidative role in multiple myeloma patients receiving autologous hematopoietic stem cell transplantation: a randomized controlled clinical trial.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Trial
- The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.Annals of medicine · 2026Review
- A Higher Burden of Abnormal Antioxidant-, Nutritional-, and Inflammation-Related Biomarkers Is Associated with Shoulder-Hand Syndrome, Hand Edema, and Short-Term Upper-Limb Outcomes During Stroke Rehabilitation.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Organic Zinc Supplementation on Gut Microbiota and Health-Related Biomarkers in Healthy Adult Dogs.Biological trace element research · 2026Article
- Ameliorative Effect of Green Bimetallic Zinc Oxide-Magnesium Oxide Nanoparticles Against Gastric Ulcer in Rats via Modulation of Oxidative Stress, Inflammatory Cascades, Nrf2/NF-κB Signaling, Angiogenic VEGF Expression.Biological trace element research · 2026Article
- Design and Development of Solvent-Sensitive Zn(II)/Al(III) Responsive Chemosensor: Extension to the Real-World Application.ChemPlusChem · 2026Article
- Amino Acid Complexed Minerals Zn, Mn, and Cu Improve Bone and Intestinal Characteristics in Laying Pullets.Biological trace element research · 2026Article
- Polyphenol mediated zinc-oxygen synergistic hydrogel remodels senescent microenvironment for periodontal tissue regeneration.Nature communications · 2026Article
- Article
- Oxidative Stress, Glutathione System Activity, and Zinc/Selenium Imbalance in Adult Measles of Varying Severity According to Vaccination Status.Infection and drug resistance · 2026Article
- The impact of smoking on serum zinc levels among Sudanese adults: a case-control study.The Pan African medical journal · 2026Article
- Water buffalo milk: physicochemical, nutritional properties, and potential benefits for human health.Frontiers in nutrition · 2026Review
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study.Frontiers in nutrition · 2026Article
- Metalloimmunotherapies: metal-driven regulatory networks in the immune microenvironment.Frontiers in immunology · 2026Review
- Construction of a Risk Identification Model Based on Electrolytes and Related Factors for Nausea and Vomiting in Pregnancy: A Secondary Analysis of Clinical Trial Data.International journal of women's health · 2026Article
- Bidirectional association between zinc and liver cirrhosis: evidence from mendelian randomization and clinical validation.Frontiers in genetics · 2026Article
- Serum zinc deficiency and progression of cardiovascular- kidney-metabolic syndrome.Frontiers in nutrition · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essentiality of zinc as a trace mineral in human health has been recognized for over five decades. Zinc deficiency, caused by diet, genetic defects, or diseases, can cause growth retardation, delayed sexual maturation, depressed immune response, and abnormal cognitive functions in humans. Zinc supplementation in zinc-deficient individuals can overcome or attenuate these abnormalities, suggesting zinc is an essential micro-nutrient in the body. A large number of in vitro and in vivo experimental studies indicate that zinc deficiency also causes apoptosis, cellular dysfunction, deoxyribonucleic acid (DNA) damage, and depressed immune response. Oxidative stress, due to the imbalance of reactive oxygen species (ROS) production and detoxification in the anti-oxidant defense system of the body, along with subsequent chronic inflammation, is believed to be associated with many chronic degenerative diseases such as diabetes, heart diseases, cancers, alcohol-related disease, macular degenerative disease, and neuro-pathogenesis. A large number of experimental studies including cell culture, animal, and human clinical studies have provided supportive evidence showing that zinc acts as an anti-oxidative stress agent by inhibition of oxidation of macro-molecules such as (DNA)/ribonucleic acid (RNA) and proteins as well as inhibition of inflammatory response, eventually resulting in the down-regulation of (ROS) production and the improvement of human health. In this article, we will discuss the molecular mechanisms of zinc as an anti-oxidative stress agent or mediator in the body. We will also discuss the applications of zinc supplementation as an anti-oxidative stress agent or mediator in human health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.