ReviewBrain sciences2019
Major Depressive Disorder Is Associated with Impaired Interoceptive Accuracy: A Systematic Review.
Review in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- A meta-analysis of the effects of mindfulness meditation training on self-reported interoception.Scientific reports · 2025Pooled it
- Interoception and obesity: a systematic review and meta-analysis of the relationship between interoception and BMI.International journal of obesity (2005) · 2021Pooled it
- "StudiCare Mindfulness": effects of an online mindfulness-based intervention on mindfulness, stress, and interoception in university students - a randomized controlled trial.BMC psychology · 2026Trial
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- Effects of a Chatbot-Based Intervention on Stress and Health-Related Parameters in a Stressed Sample: Randomized Controlled Trial.JMIR mental health · 2024Trial
- Neural changes in youth at high risk for bipolar disorder undergoing family-focused therapy or psychoeducation.Bipolar disorders · 2021Trial
- Listen to Your Heart-Ecological Momentary Assessment of Interoceptive Accuracy, Awareness and Sensibility: A Pilot Study.International journal of environmental research and public health · 2021Trial
- A dense-sampling investigation of interoceptive variation across the menstrual cycle: the Cyclic Hormones and Interoception with Repeated Profiling (CHIRP) Study.Brain, behavior, & immunity - health · 2026Article
- Computational mechanisms of learning and forgetting differentiate affective and substance use disorders.Molecular psychiatry · 2026Article
- Somatosensory Amplification and Psychopathological Symptoms: The Mediating Roles of Meteoropathy and Meteosensitivity.Brain sciences · 2026Article
- Physical activity intensities and depression in colorectal cancer: interoceptive accuracy as a mediator and mindfulness as a moderator.Journal of cancer survivorship : research and practice · 2026Article
- I sync, therefore I am: brain-body synchrony in typical and disordered consciousness.Neuroscience of consciousness · 2026Review
- Interoception in obsessive-compulsive and major depressive disorders.Frontiers in psychology · 2026Article
- Exploring the role of interoception in anxious traits and symptoms.Frontiers in psychiatry · 2026Article
- Interoceptive profiles of eating and weight disorders.Scientific reports · 2025Article
- Body Shame Predicts Healthcare Discomfort and Avoidance in College Women Through the Mechanism of Low Body Responsiveness.International journal of behavioral medicine · 2025Article
- Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.Neuroscience bulletin · 2025Review
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interoception is the sense of the physiological condition of the entire body. Impaired interoception has been associated with aberrant activity of the insula in major depressive disorder (MDD) during heartbeat perception tasks. Despite clinical relevance, studies investigating interoceptive impairments in MDD have never been reviewed systematically according to the guidelines of the PRISMA protocol, and therefore we collated studies that assessed accuracy in detecting heartbeat sensations (interoceptive accuracy, IAc) in MDD (databases: PubMed/Medline, PsycINFO, and PsycARTICLES). Out of 389 records, six studies met the inclusion criteria. The main findings suggest that (i) moderately depressed samples exhibit the largest interoceptive deficits as compared with healthy adults. (ii) difficulties in decision making and low affect intensity are correlated with low IAc, and (iii) IAc seems to normalize in severely depressed subjects. These associations may be confounded by sex, anxiety or panic disorder, and intake of selective serotonin reuptake inhibitors. Our findings have implications for the development of interoceptive treatments that might relieve MDD-related symptoms or prevent relapse in recurrent depression by targeting the interoceptive nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.