ArticleSchizophrenia bulletin2020
Multimodal Magnetic Resonance Imaging Data Fusion Reveals Distinct Patterns of Abnormal Brain Structure and Function in Catatonia.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06176456 (Interventional Triple-negative Placebo-controlled Personalized Prospective Study "Evaluation of the Efficacy and Safety of Noninvasive Neuromodulation of TMS in Subjects With Catatonia"), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventional Triple-negative Placebo-controlled Personalized Prospective Study "Evaluation of the Efficacy and Safety of Noninvasive Neuromodulation of TMS in Subjects With Catatonia"
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional neuroimaging in patients with catatonia: A systematic review.Journal of psychosomatic research · 2024Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Going Back to Kahlbaum's Psychomotor (and GABAergic) Origins: Is Catatonia More Than Just a Motor and Dopaminergic Syndrome?Schizophrenia bulletin · 2020Pooled it
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- Obsessive-compulsive and catatonic symptoms in the early stages of psychosis: Are they related?European archives of psychiatry and clinical neuroscience · 2025Article
- Parkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach.Schizophrenia bulletin · 2025Article
- Sensori- and psychomotor abnormalities, psychopathological symptoms and functionality in schizophrenia-spectrum disorders: a network analytic approach.Schizophrenia (Heidelberg, Germany) · 2025Article
- Correlation Analysis of Acute Psychotic Symptom Domain Severity and Fractional Anisotropy of Brain White Matter Tracts in Schizophrenia.Sovremennye tekhnologii v meditsine · 2025Article
- Exploring cerebellar transcranial magnetic stimulation in post-stroke limb dysfunction rehabilitation: a narrative review.Frontiers in neuroscience · 2025Review
- Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a transdiagnostic network analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- Catatonia.Nature reviews. Disease primers · 2024Review
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.Brain : a journal of neurology · 2024Article
- The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Brain connectivity disruptions in PTSD related to early adversity: a multimodal neuroimaging study.European journal of psychotraumatology · 2024Article
- [German version of the Northoff scale for subjective experience in catatonia (NSSC-dv) : A validated instrument for examination of the subjective experience in catatonia].Der Nervenarzt · 2024Article
- Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series.SAGE open medical case reports · 2024Article
- The covariant structural and functional neuro-correlates of cognitive impairments in patients with end-stage renal diseases.Frontiers in neuroscience · 2024Article
- Review
- Different faces of catatonia and how to approach them.European archives of psychiatry and clinical neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catatonia is a nosologically unspecific syndrome, which subsumes a plethora of mostly complex affective, motor, and behavioral phenomena. Although catatonia frequently occurs in schizophrenia spectrum disorders (SSD), specific patterns of abnormal brain structure and function underlying catatonia are unclear at present. Here, we used a multivariate data fusion technique for multimodal magnetic resonance imaging (MRI) data to investigate patterns of aberrant intrinsic neural activity (INA) and gray matter volume (GMV) in SSD patients with and without catatonia. Resting-state functional MRI and structural MRI data were collected from 87 right-handed SSD patients. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). A multivariate analysis approach was used to examine co-altered patterns of INA and GMV. Following a categorical approach, we found predominantly frontothalamic and corticostriatal abnormalities in SSD patients with catatonia (NCRS total score ≥ 3; n = 24) when compared to SSD patients without catatonia (NCRS total score = 0; n = 22) matched for age, gender, education, and medication. Corticostriatal network was associated with NCRS affective scores. Following a dimensional approach, 33 SSD patients with catatonia according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision were identified. NCRS behavioral scores were associated with a joint structural and functional system that predominantly included cerebellar and prefrontal/cortical motor regions. NCRS affective scores were associated with frontoparietal INA. This study provides novel neuromechanistic insights into catatonia in SSD suggesting co-altered structure/function-interactions in neural systems subserving coordinated visuospatial functions and motor behavior.
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