Evidence map›Paper›PMID 31174102›Full record

ArticleNeuroImage. Clinical2019

Structural anomaly in the reticular formation in narcolepsy type 1, suggesting lower levels of neuromelanin.

Natasha Morales Drissi, Marcel Warntjes, Alexander Wessén, Attila Szakacs, Niklas Darin, Tove Hallböök, Anne-Marie Landtblom, Helena Gauffin, Maria Engström

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Orexin effect on physiological pulsations of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Natasha Morales DrissiDepartment of Medical and Health Sciences (IMH), Linköping University, 581 83 Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, 581 83 Linköping, Sweden.
Marcel WarntjesDepartment of Medical and Health Sciences (IMH), Linköping University, 581 83 Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, 581 83 Linköping, Sweden.
Alexander WessénLinköping University, 581 83 Linköping, Sweden.
Attila SzakacsDepartment of Pediatrics, Queen Silvia Children's Hospital, Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, 416 50 Gothenburg, Sweden.
Niklas DarinDepartment of Pediatrics, Queen Silvia Children's Hospital, Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, 416 50 Gothenburg, Sweden.
Tove HallböökDepartment of Pediatrics, Queen Silvia Children's Hospital, Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, 416 50 Gothenburg, Sweden.
Anne-Marie LandtblomCenter for Medical Image Science and Visualization, Linköping University, 581 83 Linköping, Sweden; Department of Clinical and Experimental Medicine (IKE), Linköping University, 581 83 Linköping, Sweden; Department of Neuroscience, Uppsala University, 752 36 Uppsala, Sweden.
Helena GauffinDepartment of Clinical and Experimental Medicine (IKE), Linköping University, 581 83 Linköping, Sweden.
Maria EngströmDepartment of Medical and Health Sciences (IMH), Linköping University, 581 83 Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, 581 83 Linköping, Sweden. Electronic address: maria.engstrom@liu.se.
Linköping University · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate structural changes in the brain stem of adolescents with narcolepsy, a disorder characterized by excessive daytime sleepiness, fragmented night-time sleep, and cataplexy. For this purpose, we used quantitative magnetic resonance imaging to obtain R1 and R2 relaxation rates, proton density, and myelin maps in adolescents with narcolepsy (n = 14) and healthy controls (n = 14). We also acquired resting state functional magnetic resonance imaging (fMRI) for brainstem connectivity analysis. We found a significantly lower R2 in the rostral reticular formation near the superior cerebellar peduncle in narcolepsy patients, family wise error corrected p = .010. Narcolepsy patients had a mean R2 value of 1.17 s

Indexed as

MelaninsAdolescentFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNarcolepsyNeuroimagingReticular FormationYoung AdultMelaninsneuromelaninLocus coeruleusMyelinNeuromelaninOrexin/hypocretinQuantitative MRI (qMRI)Relaxation time

Identifiers

PMID31174102
PMCPMC6551567
OpenAlexW2947694950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.