ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020
Reward-Related Brain Activity Prospectively Predicts Increases in Alcohol Use in Adolescents.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.Nature communications · 2026Article
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Neural reward processing among children with conduct disorder and mild traumatic brain injury in the ABCD study.Psychological medicine · 2025Article
- Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth.bioRxiv : the preprint server for biology · 2025Article
- Multilevel Correlates of Youth Delinquent Behaviors: An Exploratory Analysis of Socioeconomic Context, Psychological Traits, and Task-Based Neural Activation in the ABCD Study.Social science insights and applications · 2025Article
- Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study.Translational psychiatry · 2025Article
- Modeling escalation of drug intake to identify molecular targets for treating substance use disorders: A slippery slope upward.Neuroscience and biobehavioral reviews · 2025Review
- Electrophysiological indices of reward anticipation as ADHD risk and prognostic biomarkers.European child & adolescent psychiatry · 2025Article
- Risk Assessment of Maladaptive Behaviors in Adolescents: Nutrition, Screen Time, Prenatal Exposure, Childhood Adversities - Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- The Influence of Substance Use on Sleep Duration Among South Korean Adolescents by Sex: A Secondary Analysis.Journal for specialists in pediatric nursing : JSPN · 2025Article
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- An investigation of multimodal predictors of adolescent alcohol initiation.Drug and alcohol dependence · 2024Article
- Corticostriatal responses to social reward are linked to trait reward sensitivity and subclinical substance use in young adults.Social cognitive and affective neuroscience · 2024Article
- Corticostriatal Responses to Social Reward are Linked to Trait Reward Sensitivity and Subclinical Substance Use in Young Adults.bioRxiv : the preprint server for biology · 2024Article
- Sleep-Related Predictors of Risk for Alcohol Use and Related Problems in Adolescents and Young Adults.Alcohol research : current reviews · 2024Review
- Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.Behavioural brain research · 2023Article
- Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.Current behavioral neuroscience reports · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAltered activity within reward-related neural regions, including the ventral striatum (VS) and medial prefrontal cortex (mPFC), is associated with concurrent problematic substance use. The aims of the present study were (a) to identify patterns of reward-related neural activity that prospectively predicted changes in alcohol use 2 years after magnetic resonance imaging in a sample of adolescents, and (b) to examine whether these patterns differed by sex. We also tested whether depression symptoms or impulsivity mediated associations between neural activity and future alcohol use.
methodParticipants were 262 adolescents (129 male and 133 female) of Mexican origin who completed the Monetary Incentive Delay task during a functional magnetic resonance imaging scan at age 16. Participants reported on their alcohol use at ages 16 and 18.
resultsResults indicated that different patterns of reward-related neural activity predicted future increases in alcohol use for male and female adolescents. In boys, higher VS activity during reward anticipation and average ventral mPFC activity during reward feedback predicted increases in alcohol use from age 16 to 18 years; in girls, higher dorsal mPFC activity and blunted VS activity during reward anticipation predicted increases in alcohol use from age 16 to 18 years. Depression symptoms or impulsivity did not mediate these associations.
conclusionThe results suggest that different pathways of risk may lead to problematic alcohol use for adolescent boys and girls. These sex differences in neural risk pathways have important implications for prevention and intervention approaches targeting Mexican-origin youth.
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