Evidence map›Paper›PMID 31173857›Full record

ArticleJournal of structural biology2019

VfoldLA: A web server for loop assembly-based prediction of putative 3D RNA structures.

Xiaojun Xu, Chenhan Zhao, Shi-Jie Chen

Abstract read
In one paragraph

Article in Journal of structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue.Computational and structural biotechnology journal · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. RNA 3D Structure Comparison Using RNA-Puzzles Toolkit.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. IsRNA1:Journal of chemical theory and computation · 2021
    Article
  14. RNA 3D Structure Prediction Using Coarse-Grained Models.Frontiers in molecular biosciences · 2021
    Review
  15. Predicting RNA Scaffolds with a Hybrid Method of Vfold3D and VfoldLA.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  16. Article
  17. 3dRNA: Building RNA 3D structure with improved template library.Computational and structural biotechnology journal · 2020
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaojun XuInstitute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, China.
Chenhan ZhaoDepartment of Physics, Department of Biochemistry, and Informatics Institute, University of Missouri, Columbia, MO 65211, USA.
Shi-Jie ChenDepartment of Physics, Department of Biochemistry, and Informatics Institute, University of Missouri, Columbia, MO 65211, USA. Electronic address: chenshi@missouri.edu.

Funding

Statistical Mechanics of RNA FoldingR01GM063732 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHI-JIE · 2003 to 2018
$3.2M
New computational tools for predicting ion effects in RNA structuresR01GM117059 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHI-JIE · 2017 to 2020
$1.2M
NIGMS NIH HHS R01 GM063732NIGMS NIH HHS R01 GM117059
6 · The paper itself

Abstract

RNA three-dimensional (3D) structures are critical for RNA cellular functions. However, structure prediction for large and complex RNAs remains a challenge, which hampers our understanding of RNA structure-function relationship. We here report a new web server, the VfoldLA server (http://rna.physics.missouri.edu/vfoldLA), for the prediction of RNA 3D structures from nucleotide sequences and base-pair information (2D structure). This server is based on the recently developed VfoldLA, a model that classifies the single-stranded loops (junctions) into four different types and according to the loop-helix connections, assembles RNA 3D structures from the loop/junction templates. The VfoldLA web server provides a user-friendly online interface for a fully automated prediction of putative 3D RNA structures using VfoldLA. With a single-RNA or RNA-RNA complex sequence and 2D structure as input, the server generates structure(s) with the JSmol visualization along with a downloadable PDB file. The output result may serve as useful scaffolds for future structure refinement studies.

Indexed as

Nucleic Acid ConformationSoftwareUser-Computer InterfaceBase SequenceComputational BiologyInternetModels, MolecularRNARNALoop templatesRNAStructure predictionVfoldLA

Identifiers

PMID31173857
PMCPMC6711797

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.