ArticleMolecular genetics & genomic medicine2019
A comprehensive immune repertoire study for patients with pulmonary tuberculosis.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Exploration of shared features of B cell receptor and T cell receptor repertoires reveals distinct clonotype clusters.Frontiers in immunology · 2022Article
- Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy.Cancer discovery · 2020Article
- A comprehensive immune repertoire study for patients with pulmonary tuberculosis.Molecular genetics & genomic medicine · 2019Article
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Authors and funding
10 authors.
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Abstract
backgroundTuberculosis (TB) is a major global health problem and has replaced HIV as the leading cause of death from a single infectious agent.
methodsHere, we applied high throughput sequencing to study the immune repertoire of nine pulmonary tuberculosis patients and nine healthy control samples.
resultsTuberculosis patients and healthy controls displayed significantly different high express clones and distinguishable sharing of CDR3 sequences. The TRBV and TRBJ gene usage showed higher expression clones in patients than in controls and we also found specific high express TRBV and TRBJ gene clones in different groups. In addition, six highly expressed TRBV/TRBJ combinations were detected in the CD4 group, 21 in the CD8 group and 32 in the tissue group.
conclusionIn conclusion, we studied the patients with tuberculosis as well as healthy control individuals in order to understand the characteristics of immune repertoire. Sharing of CDR3 sequences and differential expression of genes was found among the patients with tuberculosis which could be used for the development of potential vaccine and targets treatment.
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