ArticleInvestigative ophthalmology & visual science2019
Impaired Retinal Vascular Reactivity in Diabetic Retinopathy as Assessed by Optical Coherence Tomography Angiography.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed.
- Trial
- The Association of Retinal Capillary Density and Retinal Thickness in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances in Structural and Functional Retinal Imaging and Biomarkers for Early Detection of Diabetic Retinopathy.Biomedicines · 2024Review
- Dissecting Multiparametric Cerebral Hemodynamics using Integrated Ultrafast Ultrasound and Multispectral Photoacoustic Imaging.bioRxiv : the preprint server for biology · 2023Article
- Variability of Vascular Reactivity in the Retina and Choriocapillaris to Oxygen and Carbon Dioxide Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2023Article
- Retinal microvasculature and vasoreactivity changes in hypertension using optical coherence tomography-angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Observational
- Correlation Between Laser Speckle Flowgraphy and OCT-Derived Retinal and Choroidal Metrics in Healthy Human Eye.Translational vision science & technology · 2022Article
- Diagnosis of colour vision deficits using eye movements.Scientific reports · 2022Article
- OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.Investigative ophthalmology & visual science · 2022Article
- Effects of chronic mild hyperoxia on retinal and choroidal blood flow and retinal function in the DBA/2J mouse model of glaucoma.PloS one · 2022Article
- Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2021Article
- Optical Coherence Tomography Angiography-Derived Flux As a Measure of Physiological Changes in Retinal Capillary Blood Flow.Translational vision science & technology · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- The Effect of Software Versions on the Measurement of Retinal Vascular Densities Using Optical Coherence Tomography Angiography.Current eye research · 2021Article
- Retinal Vascular Response to Hyperoxia in Patients with Diabetes Mellitus without Diabetic Retinopathy.Journal of ophthalmology · 2021Article
- Retinal imaging demonstrates reduced capillary density in clinically unimpairedAlzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Diabetic mice have retinal and choroidal blood flow deficits and electroretinogram deficits with impaired responses to hypercapnia.PloS one · 2021Article
- 3D Retinal Vessel Density Mapping With OCT-Angiography.IEEE journal of biomedical and health informatics · 2020Article
- Retinal Vascular Reactivity in Type 1 Diabetes Patients Without Retinopathy Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Purpose: To assess retinal vascular reactivity in healthy controls and subjects with diabetic retinopathy (DR). Methods: A total of 22 healthy control eyes and 16 eyes with DR were enrolled. Images were acquired using a commercially available swept-source optical coherence tomography angiography (SS-OCTA) system. Three conditions were tested for each patient (hyperoxia, hypercapnia, and room-air) by employing a non-rebreathing apparatus that delivered appropriate gas mixtures (100% O2, 5% CO2, room air). Vessel skeleton density (VSD) and vessel diameter index (VDI) were compared between the conditions using mixed-model ANOVA adjusting for age and hypertension. Significant gas or interaction effects were followed by a Bonferroni adjusted pairwise post hoc analysis. Statistical significance was defined at P < 0.05. Results: The mixed-model ANOVA of the VSD found a significant intraindividual gas effect (F[2, 70] = 20.3, P < 0.001) and intergroup effect (F[1, 35] = 6.9, P = 0.001), and interaction effects (F[2, 70] = 4.6, P = 0.03). The post hoc pairwise comparison found significant differences among all three gas conditions in the healthy controls. In the subjects with DR, there were significant differences in VSD between hyperoxic and room air, and between hyperoxic and hypercapnic conditions, but not between hypercapnic and room-air conditions. Similar results were found for VDI. Conclusions: The retinal capillaries, assessed with SS-OCTA, in subjects with DR preferentially reacted to hyperoxia but not hypercapnia, while the healthy controls reacted to both. The difference in the vascular reactivity may be indicative of the underlying pathophysiology of DR.
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Registered trials
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