Evidence map›Paper›PMID 31172846›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Psychological resilience is linked to motor strength and gait endurance in early multiple sclerosis.

Sylvia Klineova, Rachel Brandstadter, Michelle T Fabian, Ilana Katz Sand, Stephen Krieger, Victoria M Leavitt, Christina Lewis, Claire S Riley, Fred Lublin, Aaron E Miller and 1 more

Open access · greenAbstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Sleep disturbance and memory dysfunction in early multiple sclerosis.Annals of clinical and translational neurology · 2021
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sylvia KlineovaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0406-0460
Rachel BrandstadterDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle T FabianDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ilana Katz SandDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephen KriegerDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Victoria M LeavittDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Christina LewisDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Claire S RileyDepartment of Neurology, Columbia University Medical Center, New York, NY, USA.
Fred LublinDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aaron E MillerDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
James F SumowskiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6111-4907
Icahn School of Medicine at Mount Sinai · USColumbia University Irving Medical Center · US

Funding

Reserve against Disability in Early Multiple Sclerosis (RADIEMS) Longitudinal Cohort StudyR01HD082176 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SUMOWSKI, JAMES FRANCIS · 2016 to 2025
$6.6M
NICHD NIH HHS R01 HD082176
6 · The paper itself

Abstract

backgroundPsychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in multiple sclerosis (MS).

objectiveTo determine whether psychological resilience explains differential objective cognitive and motor functioning in persons with early MS.

methodsPsychological resilience was assessed in 185 patients with early MS and 50 matched healthy controls with the

resultsHigher CDRS-10 among patients was linked to better MSFC and motor outcomes (but not cognition), with the most robust relationships for gross motor function (grip strength, gait endurance). Findings were independent of mood and fatigue. CDRS-10 was unrelated to MS disease burden. CDRS-10 was also specifically linked to motor outcomes in healthy controls.

conclusionFunctional outcomes vary across persons with MS, even when disease burden and neurologic disability are low. These findings identify high psychological resilience as a non-disease-specific contributor to motor strength and endurance, which may explain differential outcomes across patients.

Indexed as

GaitMultiple SclerosisResilience, PsychologicalAdolescentCognitionDisability EvaluationFatigueFemaleHumanscognitive performancemotor functionMultiple sclerosispsychological resilience

Identifiers

PMID31172846
PMCPMC6898764
OpenAlexW2968773748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.