Evidence map›Paper›PMID 31172810›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention.

Nandita Raikwar, Cameron Braverman, Peter M Snyder, Robert A Fenton, David K Meyerholz, Francois M Abboud, Sailesh C Harwani

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Possible organ-protective effects of renal denervation: insights from basic studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Actions of immune cells in the hypertensive kidney.Current opinion in nephrology and hypertension · 2020
    Review
  11. Review
  12. Inflammatory macrophages in the kidney contribute to salt-sensitive hypertension.American journal of physiology. Renal physiology · 2020
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nandita RaikwarDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Cameron BravermanDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Peter M SnyderDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
David K MeyerholzDivision of Comparative Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0003-1552-3253
Francois M AbboudDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Sailesh C HarwaniDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
University of Iowa · USAarhus University · DK

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
The Neuro-Immuno Axis in a Genetic Model of HypertensionK08HL119588 · NHLBI · UNIVERSITY OF IOWA · PI HARWANI, SAILESH · 2014 to 2018
$733k
NHLBI NIH HHS K08 HL119588NHLBI NIH HHS L30 HL134111NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Cholinergic receptor activation leads to premature development of hypertension and infiltration of proinflammatory CD161a

Indexed as

Blood PressureKidneyNicotineNicotinic AgonistsRenal ReabsorptionSympathectomy, ChemicalAnimalsAntibodies, MonoclonalDisease Models, AnimalHypertensionInflammation MediatorsMacrophagesMaleNK Cell Lectin-Like Receptor Subfamily BPhenolRats, Inbred SHRAntibodies, MonoclonalInflammation MediatorsKlrb1a protein, mouseNicotineNicotinic AgonistsNK Cell Lectin-Like Receptor Subfamily BPhenolSlc12a1 protein, ratSodiumSolute Carrier Family 12, Member 1adrenergicCD161CD68cholinergichypertensioninflammationinnate immunitymacrophagenicotinerenalrenal denervation

Identifiers

PMID31172810
PMCPMC6766722
OpenAlexW2948610822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.