Evidence map›Paper›PMID 31172717›Full record

ArticleAllergy, asthma & immunology research2019

Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps.

Yunyun Zhang, Hongfei Lou, Yang Wang, Ying Li, Luo Zhang, Chengshuo Wang

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05325489 (Comparison Between the Effect of Nebulized Budesonide and Intranasal Budesonide Spray on Children With Adenotonsillar Hypertrophy), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05325489 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

Comparison Between the Effect of Nebulized Budesonide and Intranasal Budesonide Spray on Children With Adenotonsillar Hypertrophy: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorSecond Xiangya Hospital of Central South UniversityRan2022 to 2024Enrolled100ConditionsSnoring, Mouth BreathingArmsNebulized Budesonide, Intranasal Budesonide Spray
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  17. Efficacy and safety of delivery of topical medication on to the frontal sinus at different head positions after frontal sinusotomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yunyun Zhang *Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Hongfei Lou *Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-8553-812X
Yang WangBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Ying LiBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0910-9884
Chengshuo WangDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0646-5135
Beijing Tongren Hospital · CNBeijing Institute of Neurosurgery · CN

Funding

Beijing Municipal Administration of Hospitals' Mission Plan SML20150203Beijing Municipal Administration of Hospitals' Youth Programme QML20150202Beijing Technology and Business University 20181045Capital Health Development Foundation 2016-1-2052National Key R & D Program of China 2016YFC20160905200National Key R & D Program of China 2018YFC0116800National Natural Science Foundation of China 81400444National Natural Science Foundation of China 81420108009National Natural Science Foundation of China 81470678National Natural Science Foundation of China 81630023
6 · The paper itself

Abstract

purposeCorticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid preparations administered via different routes for the treatment of chronic rhinosinusitis with nasal polyps has not been reported. To compare the efficacy and safety of steroids administered via the oral, intranasal spray and transnasal nebulization routes in the management of ECRSwNP over a short course.

methodsOverall, 91 patients with ECRSwNP were recruited prospectively and randomized to receive either oral methylprednisolone, budesonide inhalation suspension (BIS) via transnasal nebulization, or budesonide nasal spray (BNS) for 2 weeks. Nasal symptoms and polyp sizes were assessed before and after the treatment. Similarly, nasal polyp samples were evaluated for immunological and tissue remodeling markers. Serum cortisol levels were assessed as a safety outcome.

resultsOral methylprednisolone and BIS decreased symptoms and polyp sizes to a significantly greater extent from baseline (

conclusionsA short course of BIS transnasal nebulization is more efficacious compared to BNS in the management of ECRSwNP and is safer than oral methylprednisolone with respect to hypothalamic-pituitary-adrenal axis function.

Indexed as

Chronic rhinosinusitisglucocorticoidsnasal polypsnasal spraytransnasal nebulization

Identifiers

PMID31172717
PMCPMC6557780
OpenAlexW2952648852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.