ArticlePharmacoepidemiology and drug safety2019
Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources.
Article in Pharmacoepidemiology and drug safety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- In-hospital mortality of heat-related disease associated with wet bulb globe temperature: a Japanese nationwide inpatient data analysis.International journal of biometeorology · 2025Article
- Application of physiological network mapping in the prediction of survival in critically ill patients with acute liver failure.Scientific reports · 2024Article
- Validation of diagnoses of liver disorders in users of systemic azole antifungal medication in Sweden.BMC gastroenterology · 2024Article
- Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record.Digestive diseases and sciences · 2022Article
- Reply to Rezahosseini.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Oral Fluoroquinolone Use and the Risk of Acute Liver Injury: A Nationwide Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Statin Use and Severe Acute Liver Injury Among Patients with Elevated Alanine Aminotransferase.Clinical epidemiology · 2022Article
- Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users.Drug safety · 2021Article
- Factors associated with primary nonadherence to newly initiated direct oral anticoagulants in patients with nonvalvular atrial fibrillation.Journal of managed care & specialty pharmacy · 2021Observational
- Medication-Related Problems in Older People with Multimorbidity in Catalonia: A Real-World Data Study with 5 Years' Follow-Up.Journal of clinical medicine · 2021Article
- Medication-related problems in older people in Catalonia: A real-world data study.Pharmacoepidemiology and drug safety · 2021Article
- Multimorbidity patterns, polypharmacy and their association with liver and kidney abnormalities in people over 65 years of age: a longitudinal study.BMC geriatrics · 2020Article
- Is it time to use real-world data from primary care in Alzheimer's disease?Alzheimer's research & therapy · 2020Article
- Utility of a Computerized ICD-10 Algorithm to Identify Idiosyncratic Drug-Induced Liver Injury Cases in the Electronic Medical Record.Drug safety · 2020Article
- Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources.Pharmacoepidemiology and drug safety · 2019Article
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15 authors.
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Abstract
purposeValidating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs).
methodsCase validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. Three ALI definitions were evaluated: primary (specific hospital discharge codes), secondary (specific and nonspecific hospital discharge codes), and tertiary (specific and nonspecific hospital and outpatient codes). The validation included review of patient profiles (EpiChron and SIDIAP) and of clinical data from medical records (EpiChron and Denmark). ALI cases were confirmed when liver enzyme values met a definition by an international working group.
resultsOverall PPVs (95% CIs) for the study ALI definitions were, for the primary ALI definition, 84% (60%-97%) (EpiChron), 60% (26%-88%) (SIDIAP), and 74% (60%-85%) (Denmark); for the secondary ALI definition, 65% (45%-81%) (EpiChron), 40% (19%-64%) (SIDIAP), and 70% (64%-77%) (Denmark); and for the tertiary ALI definition, 25% (18%-34%) (EpiChron), 8% (7%-9%) (SIDIAP), and 47% (42%-52%) (Denmark). The overall PPVs were higher for specific than for nonspecific codes and for hospital discharge than for outpatient codes. The nonspecific code "unspecified jaundice" had high PPVs in Denmark.
conclusionsPPVs obtained apply to patients using antidepressants without preexisting liver disease or ALI risk factors. To maximize validity, studies on ALI should prioritize hospital specific discharge codes and should include hospital codes for unspecified jaundice. Case validation is required when ALI outpatient cases are considered.
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