ArticleJPEN. Journal of parenteral and enteral nutrition2020
Association of PROtein and CAloric Intake and Clinical Outcomes in Adult SEPTic and Non-Septic ICU Patients on Prolonged Mechanical Ventilation: The PROCASEPT Retrospective Study.
Article in JPEN. Journal of parenteral and enteral nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Nitrogen balance and outcomes in critically ill patients: A systematic review and meta-analysis.Frontiers in nutrition · 2022Pooled it
- Effects of permissive hypocaloricWorld journal of gastroenterology · 2021Trial
- Association between energy adequacy and clinical outcomes in septic intensive care unit patients stratified by modified Nutrition Risk in the Critically Ill score.Journal of the Chinese Medical Association : JCMA · 2026Article
- Nutritional Risk and 30-Day In-Hospital Mortality in Adults With Sepsis and Septic Shock: A Retrospective Cohort Study.Journal of nursing management · 2026Article
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- Achievement of adequate nutrition contributes to maintaining the skeletal muscle area in patients with sepsis undergoing early mobilization: a retrospective observational study.BMC nutrition · 2024Article
- Prospective study of protein intake and mortality among US adults with chronic obstructive pulmonary disease.Frontiers in nutrition · 2024Article
- Higher protein intake may benefit in patients with prolonged mechanical ventilation.Frontiers in nutrition · 2024Article
- Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study.JMA journal · 2023Article
- Protein intake and outcome of critically ill patients: analysis of a large international database using piece-wise exponential additive mixed models.Critical care (London, England) · 2022Article
- Significant Published Articles in 2020 for Pharmacy Nutrition Support Practice.Hospital pharmacy · 2021Article
- Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations.Journal of intensive care · 2021Review
- Nutrition Support in the ICU-A Refresher in the Era of COVID-19.The American journal of gastroenterology · 2020Review
- Nutritional therapy in patients with sepsis: is less really more?Critical care (London, England) · 2020Article
- Elevated Interleukin-6 Levels within 72 Hours Post Admission Are Associated with Disease Progression in Nonseptic Critically Ill Children.BioMed research international · 2020Article
- Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases.Critical care (London, England) · 2019Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal nutritional support for critically ill septic patients remains unknown. This study evaluates the associations of macronutrient intake during the first week of intensive care unit (ICU) admission and long-term clinical outcomes in septic and non-septic patients.
methodsProlonged mechanically ventilated patients were retrospectively studied. The association of protein (low: <0.8 g/kg/d, medium: 0.8-1.2 g/kg/d, high >1.2 g/kg/d) and energy intake (<80%, 80%-110%, 110% of target) during days 1-3 and 4-7 after ICU admission and 6-month mortality was analyzed for septic and non-septic patients separately.
resultsA total of 423 patients were investigated. Of these, 297 had sepsis. In the sepsis group, medium protein intake at days 4-7 was associated with lower 6-month mortality (hazard ratio [HR]: 0.646, 95% confidence interval [CI]: 0.418-0.996, P=0.048) compared with high intake. In the non-sepsis group, early high and late low protein intake were associated with higher 6-month mortality (HR: 3.902, 95% CI: 1.505-10.115, P=0.005; HR: 2.642, 95% CI: 1.128-6.189, P=0.025) compared with low and high protein intake, respectively. For energy intake, late energy intake of >110% was associated with decreased mortality in septic patients (HR: 0.400, 95% CI: 0.222-0.721, P=0.002), whereas in non-septic patients, late medium energy intake (80%-110%) was associated with better survival (HR: 0.379, 95% CI: 0.175-0.820, P=0.014), both compared with low energy intake.
conclusionDivergent associations of macronutrient intake were found; early high protein intake in non-septic patients, but not in septic patients, was found to be associated with higher 6-month mortality.
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