ArticleOral and maxillofacial surgery2019
Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study.
Article in Oral and maxillofacial surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Pooled it
- Effectiveness of a protocol with antimicrobial photodynamic therapy for treating osteoradionecrosis: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Retrospective analysis of tooth extraction and osteoradionecrosis after low-dose rate brachytherapy for patients with tongue cancer.Oral radiology · 2024Article
- Risk factor analysis and development of predictive models for osteoradionecrosis in patients with nasopharyngeal carcinoma after concurrent chemoradiotherapy.American journal of cancer research · 2024Article
- A reappraisal to "To extract or not extract teeth prior to head and neck radiotherapy?"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Risk factors for pathological fracture in patients with mandibular osteoradionecrosis.Scientific reports · 2023Article
- Osteonecrosis of the Jaw.Dentistry journal · 2023Review
- Pilot investigation on the dose-dependent impact of irradiation on primary human alveolar osteoblasts in vitro.Scientific reports · 2021Article
- Patients with head and neck cancer treated with radiotherapy: Their experiences after 6 months of prophylactic tooth extractions and temporary removable dentures.Clinical and experimental dental research · 2021Article
- Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma.Radiation oncology (London, England) · 2021Article
- Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?Oral diseases · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws.
methodsThis is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT.
resultsSixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT.
conclusionsDental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.
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