Evidence map›Paper›PMID 31172380›Full record

ArticleJournal of clinical immunology2019

Chronic Granulomatous Disorder-Associated Colitis Can Be Accurately Evaluated with MRI Scans and Fecal Calprotectin Level.

David M Lowe, Philip J Smith, Fernando Moreira, Sarita Workman, Helen Braggins, Nikolaos Koukias, Matthew S Buckland, Peter Wylie, Stuart A Taylor, Charles D Murray

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. How I Treat: Chronic granulomatous disease.Journal of human immunity · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David M LoweInstitute of Immunity and Transplantation, University College London, Royal Free Campus, Pond Street, London, NW3 2QG, UK. d.lowe@ucl.ac.uk.ORCID 0000-0001-6102-2375
Philip J SmithDepartment of Gastroenterology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Fernando MoreiraDepartment of Clinical Immunology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Sarita WorkmanDepartment of Clinical Immunology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Helen BragginsDepartment of Immunology, Great Ormond Street Hospital, London, WC1N 3JH, UK.
Nikolaos KoukiasDepartment of Gastroenterology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Matthew S BucklandInstitute of Immunity and Transplantation, University College London, Royal Free Campus, Pond Street, London, NW3 2QG, UK.
Peter WylieDepartment of Radiology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Stuart A TaylorCentre for Medical Imaging, University College London Hospital, University College London, Euston Road, London, NW1 2BU, UK.
Charles D MurrayDepartment of Gastroenterology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.

Funding

Medical Research Council G0902022
6 · The paper itself

Abstract

purposeColitis is a common and serious complication of chronic granulomatous disorder (CGD) and requires assessment. Colonoscopy is invasive and carries risks of serious complication. We therefore assessed non-invasive monitoring via magnetic resonance imaging (MRI). We also evaluated fecal calprotectin (FCP), the Harvey-Bradshaw index (HBI) clinical score, and serum cytokines.

methodsWe recruited 10 patients with CGD (8 males, mean age 29.6 years), scored a modified HBI, and obtained stool for FCP. The following day we took blood for cytokine measurement via Luminex, performed MR enterography (scored by two independent radiologists using three systems: London score, CDMI, and MaRIA) followed by colonoscopy with disease activity measurement via ulcerative colitis endoscopic index of severity (UCEIS). We assessed patient experience after each investigation and overall preference with follow-up questionnaires.

resultsMRI scores correlated well with colonoscopic gold standard (for London score R

conclusionsMRI and fecal calprotectin are useful methods for monitoring CGD colitis and should reduce the need for colonoscopy in these patients. IL-12 may represent an appropriate target for treatment.

Indexed as

AdultColitisColonoscopyCytokinesFecesFemaleGranulomatous Disease, ChronicHumansLeukocyte L1 Antigen ComplexMagnetic Resonance ImagingMaleYoung AdultCytokinesLeukocyte L1 Antigen Complexendoscopyinflammatory bowel diseaseNon-invasive assessmentradiology

Identifiers

PMID31172380
PMCPMC6611758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.