Evidence map›Paper›PMID 31172378›Full record

ArticleNeurosurgical review2019

CCM1/KRIT1 mutation in monozygotic twins of a polyzygotic triplet birth: genetic, clinical and radiological characteristics.

Karl Hartmann, Klaus-Peter Stein, Belal Neyazi, Ute Felbor, Sven Hethey, I Erol Sandalcioglu

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Cervical Cord Hemorrhage in Cerebral Cavernous Malformations.Journal of clinical neurology (Seoul, Korea) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Karl HartmannDepartment of Neurosurgery, KRH Hospital Nordstadt, Haltenhoffstrasse 41, 30167, Hannover, Germany. karl.hartmann@krh.eu.ORCID http://orcid.org/0000-0001-6732-952X
Klaus-Peter SteinDepartment of Neurosurgery, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Belal NeyaziDepartment of Neurosurgery, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Ute FelborDepartment of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Fleischmannstrasse 43, 17475, Greifswald, Germany.
Sven HetheyDepartment of Neuropediatrics, Kinderkrankenhaus auf der Bult, Janusz-Korczak-Allee 12, 30173, Hannover, Germany.
I Erol SandalciogluDepartment of Neurosurgery, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Otto-von-Guericke-Universität Magdeburg · DEKinderkrankenhaus auf der Bult · DEKRH Klinikum Nordstadt · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformations are focal vascular lesions of the brain, occurring sporadically or as an autosomal dominant familial form. The genetic background influences not only the clinical course but also patients' consultation and the indication to treat. We here present the rare case of monozygotic male twins of a polyzygotic triplet birth, carrying a CCM1 mutation, inherited from the mother. Both twins showed an identical site and size of a large frontobasal lesion. The genetic segregation and the clinical course in affected family members are presented and discussed.

Indexed as

ChildDiseases in TwinsHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinMaleMutationPedigreeRadiographyTwins, MonozygoticKRIT1 ProteinKRIT1 protein, humanCCM1/KRIT1 mutationMonozygotic twinsPolyzygotic triplet birth

Identifiers

PMID31172378
OpenAlexW2963364269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.