Evidence map›Paper›PMID 31172320›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2019

Contribution of heparin to recovery of incarcerated intestine in a rat incarcerated hernia model.

Yao Chen, Changfu Qin, Guanghai Wang, Ming Xiao, Guodong Xiao, Zhongda Luan, Chengchao Du, Jia Wang, Xuedong Xu

Abstract read
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In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yao ChenGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China.
Changfu QinDepartment of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, China.
Guanghai WangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, Guizhou, China.
Ming XiaoGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China.
Guodong XiaoGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China.
Zhongda LuanGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China.
Chengchao DuAffiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Jia WangGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China. edenboy_wj@sina.com.
Xuedong XuGeneral Surgery of the Third Department, The First Affiliated of Dalian Medical University, Dalian, 116600, Liaoning, China. dongzi1000@outlook.com.ORCID http://orcid.org/0000-0002-0754-7100
Dalian Medical University · CNAffiliated Hospital of North Sichuan Medical College · CNCapital Medical University · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInguinal hernias are the most common type of abdominal wall hernias. Although surgery is the only effective treatment for these hernias in adults, several problems associated with surgical treatment have been reported. If the hernia exits from a weak point of the abdominal wall, it can obstruct the bowel, thereby causing serious complications, including intestinal obstruction or strangulation. Through this study, we aimed to analyze the optimal incarceration induction time taken to cause some degree of necrosis from which recovery would be possible in a rat incarcerated abdominal wall hernia model and to determine the efficacy of heparin for expedite recovery from intestinal incarceration.

methodsA rat incarcerated abdominal wall hernia model was constructed, intestinal activity and the incarceration induction time were determined based on the color of the intestine and HE staining of intestinal sections. Heparin and procaine were sprayed onto intestinal surfaces, and their effects on the recovery from intestinal incarceration were evaluated.

resultsRecovery from intestinal incarceration would be better if the incarceration induction time was maintained below 2.5 h in our rat model, and heparin was found to be superior to procaine in the expedite recovery from intestinal incarceration, particularly immediately after relieving such intestines.

conclusionsThe results of this study are significant for planning the treatment of incarcerated inguinal hernia. Further, heparin is superior to procaine in terms of expedite recovery from intestinal incarceration.

Indexed as

AnimalsCardiovascular AgentsDisease Models, AnimalHeparinHernia, AbdominalIntestinal ObstructionIntestinesMaleNecrosisProcaineRatsRats, Sprague-DawleyRecovery of FunctionTime FactorsCardiovascular AgentsHeparinProcaineAnimal modelHeparinIncarcerated inguinal herniaIncarceration time

Identifiers

PMID31172320
OpenAlexW2949749320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.