ArticleEuropean child & adolescent psychiatry2020
Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.
Article in European child & adolescent psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Emotional and behavioral problems in the offspring of parents with schizophrenia or bipolar disorder: a controlled comparative study.Frontiers in psychiatry · 2026Article
- Frequency analysis of mood, sleep, and alcohol and nicotine use: investigating instability in bipolar I and II disorder.Frontiers in psychiatry · 2026Article
- Editorial: The role of affect regulation in bipolar disorders.Frontiers in psychiatry · 2025Article
- The impact of personality traits on the return of major depression: a case-control study.Frontiers in psychology · 2025Article
- A mixed methods pilot feasibility study of the unified protocol group psychotherapy for early bipolar disorder.Frontiers in psychiatry · 2025Article
- Psychometric property study of the Affective Lability Scale-short form in Chinese patients with mood disorders.Frontiers in psychiatry · 2023Article
- Affective lability and social functioning in severe mental disorders.European archives of psychiatry and clinical neuroscience · 2022Article
- Characterization of affective lability across subgroups of psychosis spectrum disorders.International journal of bipolar disorders · 2021Article
- A Longitudinal Study of Psychiatric Disorders in Offspring of Parents With Bipolar Disorder From Preschool to Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Affective lability across psychosis spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- The Role of Gut Microbiota in the High-Risk Construct of Severe Mental Disorders: A Mini Review.Frontiers in psychiatry · 2020Review
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Authors and funding
12 authors.
Funding
Abstract
Affective lability, defined as the propensity to experience excessive and unpredictable changes in mood, has been proposed as a potential transdiagnostic predictor of major mood and psychotic disorders. A parental diagnosis of bipolar disorder has been associated with increased affective lability in offspring. However, the association between affective lability and family history of other mood and psychotic disorders has not been examined. We measured affective lability using the self- and parent-reported Children's Affective Lability Scale in a cohort of 320 youth aged 6-17 years, including 137 offspring of a parent with major depressive disorder, 68 offspring of a parent with bipolar disorder, 24 offspring of a parent with schizophrenia, and 91 offspring of control parents. We tested differences in affective lability between groups using mixed-effects linear regression. Offspring of a parent with major depressive disorder (β = 0.46, 95% CI 0.17-0.76, p = 0.002) or bipolar disorder (β = 0.47, 95% CI 0.12-0.81, p = 0.008) had significantly higher affective lability scores than control offspring. Affective lability did not differ significantly between offspring of a parent with schizophrenia and offspring of control parents. Our results suggest that elevated affective lability during childhood is a marker of familial risk for mood disorders.
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