SynthesisSurgery today2020
Clinical- and surgery-specific risk factors for post-operative sepsis: a systematic review and meta-analysis of over 30 million patients.
Synthesis in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- An interpretable deep learning framework for predictive modeling of postoperative infections in ICU patients.PloS one · 2026Article
- Correlation between inguinal and ventral hernia repair outcomes and pre-existing comorbidity clusters: ACS-NSQIP study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Clinical application of targeted nanopore sequencing in pathogen detection in patients with sepsis.BMC infectious diseases · 2025Article
- Postoperative sepsis and its sequential impact on dementia.Critical care (London, England) · 2025Article
- Postoperative sepsis-associated neurocognitive disorder: mechanisms, predictive strategies, and treatment approaches.Frontiers in medicine · 2025Review
- Be-SNAP: the Belgian Sepsis National Action Plan.Frontiers in public health · 2025Article
- Development and validation of an ensemble learning risk model for sepsis after abdominal surgery.Archives of medical science : AMS · 2025Article
- Perioperative outcomes in male patients undergoing cystectomy, radical colorectal procedure or total pelvic exenteration.Translational andrology and urology · 2023Article
- Article
- ICU patients with infectious complications after abdominopelvic surgery: Is thoracic CT in addition to abdominal CT helpful?Annals of intensive care · 2023Article
- Obesity and infectious diseases: pathophysiology and epidemiology of a double pandemic condition.International journal of obesity (2005) · 2022Review
- Tree-based, two-stage risk factor analysis for postoperative sepsis based on Sepsis-3 criteria in elderly patients: A retrospective cohort study.Frontiers in public health · 2022Article
- Increased mortality and altered local immune response in secondary peritonitis after previous visceral operations in mice.Scientific reports · 2021Article
- Sepsis in surgical inpatients: under-recognised but with significant consequences.Irish journal of medical science · 2021Article
- Article
- Lower complication rates associated with transradial versus transfemoral flow diverting stent placement.Journal of neurointerventional surgery · 2021Article
- Nomograms Predicting the Occurrence of Sepsis in Patients following Major Hepatobiliary and Pancreatic Surgery.Gastroenterology research and practice · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-operative sepsis is a severe complication of surgery, which often worsens the clinical outcomes. While several risk factors have been identified, the importance of others remains uncertain. This systematic review and meta-analysis aimed to determine patient and surgery-related risk factors for post-operative sepsis. We reviewed Medline, the Web of Science, and the Cochrane library, systematically, for articles describing risk factors for sepsis. The role of eligible risk factors was investigated using a random-effects model, while analyzing univariate and multivariate data separately. Among 193 pro- and retrospective articles, comprising over 30 million patients, 38 eligible risk factors were selected for this meta-analysis. The patient-related risk factors associated with post-operative sepsis included male gender (odds ratio, OR 1.41), pre-existing heart failure (OR 2.53), diabetes (OR 1.41), and chronic kidney disease (OR 1.26). The surgery-related risk factors identified included emergency surgery (OR 3.38), peri-operative blood transfusion (OR 1.90), inpatient hospital stay (OR 2.31), and open surgery (OR 1.80). The adjusted overall incidence of surgical sepsis was 1.84%. In conclusion, multiple-patient and surgery-related risk factors are associated with the development of post-operative sepsis. Recognizing these risk factors could assist in the pre-operative identification of patients at risk of post-operative sepsis.
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