Evidence map›Paper›PMID 31172261›Full record

ArticleInternational journal of colorectal disease2019

Peridural analgesia does not impact survival in patients after colon cancer resection: a retrospective propensity score-adjusted analysis.

Elena F Wurster, Frank Pianka, Rene Warschkow, Pia Antony, Thorsten Brenner, Markus A Weigand, Bruno M Schmied, Markus W Büchler, Ignazio Tarantino, Alexis Ulrich

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In one paragraph

Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Elena F WursterDepartment of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Frank PiankaDepartment of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Rene WarschkowDepartment of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, Rorschacher Straße 95, 9007, St. Gallen, Switzerland.
Pia AntonyDepartment of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Thorsten BrennerDepartment of Anesthesiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Markus A WeigandDepartment of Anesthesiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Bruno M SchmiedDepartment of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, Rorschacher Straße 95, 9007, St. Gallen, Switzerland.
Markus W BüchlerDepartment of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Ignazio TarantinoDepartment of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, Rorschacher Straße 95, 9007, St. Gallen, Switzerland. ignazio.tarantino@kssg.ch.
Alexis UlrichSurgical Department I, Städtische Kliniken Neuss Lukaskrankenhaus GmbH, Lukaskrankenhaus GmbH, Preußenstraße 84, 41464, Neuss, Germany.
University Hospital Heidelberg · DEHeidelberg University · DEKantonsspital St. Gallen · CHLukaskrankenhaus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the putative impact of peridural analgesia on oncological outcome in patients undergoing resection of stages I-IV colon cancer.

methodsIn a single-center study, 876 patients undergoing resection for primary colon cancer (AJCC stages I-IV) between 2001 and 2014 were analyzed. Mean follow-up of the entire cohort was 4.2 ± 3.5 years. Patients who did and did not receive peridural analgesia were compared using Cox regression and propensity score analyses.

resultsOverall, 208 patients (23.7%) received peridural analgesia. Patients' characteristics were biased with regard to the use of peridural analgesia (propensity score 0.296 ± 0.129 vs. 0.219 ± 0.108, p < 0.001). After propensity score matching, the use of peridural analgesia had no impact on overall (HR 0.81, 95% CI 0.59-1.11, p = 0.175), cancer-specific (HR 0.72, 95% CI 0.48-1.09, p = 0.111), and disease-free survival (HR 0.89, 95% CI 0.66-1.19, p = 0.430). The 5-year overall survival after propensity score matching was 60.9% (95% CI 54.8-67.7%) for patients treated with peridural analgesia compared with 54.1% (95% CI 49.5-59.1%) for patients not treated with peridural analgesia. Cancer-specific and disease-free survival showed similar non-significant results.

conclusionsPeridural analgesia in patients after colon cancer resection was not associated with a better oncological outcome after risk adjusting in multivariable Cox regression and propensity score analyses. Hence, oncological outcome should not serve as a reason for the use of peridural analgesia in patients with colon cancer.

Indexed as

AnalgesiaKaplan-Meier EstimatePropensity ScoreAgedColonic NeoplasmsDisease-Free SurvivalFemaleHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective StudiesCancer-specific survivalColon cancerOverall survivalPeridural analgesia

Identifiers

PMID31172261
OpenAlexW2953052087

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.