Evidence map›Paper›PMID 31172249›Full record

ArticleEuropean journal of clinical pharmacology2019

Limited sampling strategy to predict mycophenolic acid area under the curve in pediatric patients with nephrotic syndrome: a retrospective cohort study.

Joanna Sobiak, Matylda Resztak, Tomasz Pawiński, Paweł Żero, Danuta Ostalska-Nowicka, Jacek Zachwieja, Maria Chrzanowska

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. An integrated sampling strategy for therapeutic mycophenolic acid monitoring in lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025
    Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joanna SobiakDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznan, Poland. jsobiak@ump.edu.pl.ORCID http://orcid.org/0000-0002-2764-1575
Matylda ResztakDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznan, Poland.
Tomasz PawińskiDepartment of Drug Chemistry, Medical University of Warsaw, 1 Banacha Street, 02-097, Warsaw, Poland.
Paweł ŻeroDepartment of Drug Chemistry, Medical University of Warsaw, 1 Banacha Street, 02-097, Warsaw, Poland.
Danuta Ostalska-NowickaDepartment of Pediatric Cardiology, Nephrology and Hypertension, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572, Poznan, Poland.
Jacek ZachwiejaDepartment of Pediatric Cardiology, Nephrology and Hypertension, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572, Poznan, Poland.
Maria ChrzanowskaDepartment of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781, Poznan, Poland.
Poznan University of Medical Sciences · PLMedical University of Warsaw · PL

Funding

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu 502-14-03306413-10156
6 · The paper itself

Abstract

purposeLimited sampling strategy (LSS) is a precise and relatively convenient therapeutic drug monitoring method. We evaluated LSSs for mycophenolic acid (MPA) in children with nephrotic syndrome treated with mycophenolic mofetil (MMF) and validated the LSSs using two different approaches.

methodsWe measured MPA plasma concentrations in 31 children using HPLC-UV method and received 37 MPA pharmacokinetic profiles (0-12 h). For six children, MPA profiles were estimated twice after two MMF doses. LSSs were developed using multilinear regression with STATISTICA and R software and validated using validation group and bootstrap method, respectively.

resultsThe best three time point equations included C

conclusionsThe most useful equations included C

Indexed as

AlgorithmsAdolescentArea Under CurveChildChild, PreschoolFemaleHumansImmunosuppressive AgentsMaleMycophenolic AcidNephrotic SyndromeRetrospective StudiesImmunosuppressive AgentsMycophenolic AcidLimited sampling strategyMycophenolic acidNephrotic syndromePediatric patientsPharmacokineticsTherapeutic drug monitoring

Identifiers

PMID31172249
OpenAlexW2962897638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.