Evidence map›Paper›PMID 31172175›Full record

Trial reportThe American journal of clinical nutrition2019

Effect of different doses of supervised exercise on food intake, metabolism, and non-exercise physical activity: The E-MECHANIC randomized controlled trial.

Corby K Martin, William D Johnson, Candice A Myers, John W Apolzan, Conrad P Earnest, Diana M Thomas, Jennifer C Rood, Neil M Johannsen, Catrine Tudor-Locke, Melissa Harris and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01264406 (Examination of Mechanisms), which is not on this map. Cited by 66 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 7 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01264406 completednot on this map

Examination of Mechanisms (E-MECHANIC) of Exercise-induced Weight Compensation

TypeobservationalSponsorPennington Biomedical Research CenterRan2010 to 2015Enrolled198ConditionsExercise, Energy, Body Weight
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 7 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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  5. Eating disorder risk during behavioral weight management in adults with overweight or obesity: A systematic review with meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
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  7. Impact of different training modalities on anthropometric outcomes in patients with obesity: A systematic review and network meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  17. Effect of an office-based intervention on visceral adipose tissue: the WorkACTIVE-P randomized controlled trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA.
William D JohnsonPennington Biomedical Research Center, Baton Rouge, LA.
Candice A MyersPennington Biomedical Research Center, Baton Rouge, LA.
John W ApolzanPennington Biomedical Research Center, Baton Rouge, LA.
Conrad P EarnestTexas A&M University, College Station, TX.
Diana M ThomasUnited States Military Academy, West Point, NY.
Jennifer C RoodPennington Biomedical Research Center, Baton Rouge, LA.
Neil M JohannsenPennington Biomedical Research Center, Baton Rouge, LA.
Catrine Tudor-LockePennington Biomedical Research Center, Baton Rouge, LA.
Melissa HarrisPennington Biomedical Research Center, Baton Rouge, LA.
Daniel S HsiaPennington Biomedical Research Center, Baton Rouge, LA.
Timothy S ChurchPennington Biomedical Research Center, Baton Rouge, LA.
Pennington Biomedical Research Center · USTexas A&M University · USUnited States Military Academy · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leanne Maree Redman · 2005 to 2026
$26.5M
Neighborhood Moderating Effects on Intervention Response in Cardiovascular HealthF32HL123242 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MYERS, CANDICE ALICIA · 2014 to 2017
$142k
NHLBI NIH HHS F32 HL123242NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundExercise is recommended for weight management, yet exercise produces less weight loss than expected, which is called weight compensation. The mechanisms for weight compensation are unclear.

objectiveThe aim of this study was to identify the mechanisms responsible for compensation.

methodsIn a randomized controlled trial conducted at an academic research center, adults (n = 198) with overweight or obesity were randomized for 24 wk to a no-exercise control group or 1 of 2 supervised exercise groups: 8 kcal/kg of body weight/wk (KKW) or 20 KKW. Outcome assessment occurred at weeks 0 and 24. Energy intake, activity, and resting metabolic rate (RMR) were measured with doubly labeled water (DLW; with and without adjustments for change in RMR), armband accelerometers, and indirect calorimetry, respectively. Appetite and compensatory health beliefs were measured by self-report.

resultsA per-protocol analysis included 171 participants (72.5% women; mean ± SD baseline body mass index: 31.5 ± 4.7 kg/m2). Significant (P < 0.01) compensation occurred in the 8 KKW (mean: 1.5 kg; 95% CI: 0.9, 2.2 kg) and 20 KKW (mean: 2.7 kg; 95% CI: 2.0, 3.5 kg) groups, and compensation differed significantly between the exercise groups (P = 0.01). Energy intake by adjusted DLW increased significantly (P < 0.05) in the 8 KKW (mean: 90.7 kcal/d; 95% CI: 35.1, 146.4 kcal/d) and 20 KKW (mean: 123.6 kcal/d; 95% CI: 64.5, 182.7 kcal/d) groups compared with control (mean: -2.3 kcal/d; 95% CI: -58.0, 53.5 kcal/d). Results were similar without DLW adjustment. RMR and physical activity (excluding structured exercise) did not differentially change among the 3 groups. Participants with higher compared with lower compensation reported increased appetite ratings and beliefs that healthy behaviors can compensate for unhealthy behaviors. Furthermore, they increased craving for sweet foods, increased sleep disturbance, and had worsening bodily pain.

conclusionsCompensation resulted from increased energy intake and concomitant increases in appetite, which can be treated with dietary or pharmacological interventions. Compensation was not due to activity or metabolic changes. This trial was registered at clinicaltrials.gov as NCT01264406.

Indexed as

EatingExerciseAdultEnergy IntakeEnergy MetabolismFemaleHumansMaleMiddle AgedSurveys and QuestionnairesWeight Losscompensationcompensatory health beliefsexerciseFood Craving Inventoryfood intakephysical activitySF-36weight loss

Identifiers

PMID31172175
PMCPMC6735935
OpenAlexW2954998201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.