SynthesisThe American journal of clinical nutrition2019
Clinical outcomes in pediatric intestinal failure: a meta-analysis and meta-regression.
Synthesis in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Conceptual and operational consistency in defining intestinal failure across randomized controlled trials: a systematic review and meta-research analysis.BMC gastroenterology · 2026Pooled it
- Gut microbiome in paediatric short bowel syndrome: a systematic review and sequencing re-analysis.Pediatric research · 2025Pooled it
- Functional Imaging for Regenerative Medicine: Tracking Vascularization of Intestinal Scaffolds.Tissue engineering. Part A · 2026Article
- Sepsis as a confounding factor in assessing liver dysfunction in parenterally fed piglets: a model for human infants with intestinal failure.Laboratory animal research · 2026Article
- Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.Annals of surgical treatment and research · 2026Article
- CT-based radiomics-clinical model for risk assessment of parenteral nutrition-associated hepatic steatosis in chronic intestinal failure and its metabolomic interpretation.Frontiers in nutrition · 2026Article
- Development of a novel tubular scaffold for tissue-engineered small intestine.Journal of pediatric surgery · 2026Article
- Recurrent thrombosis and major bleeding in children treated for VTE.Blood advances · 2025Article
- Transition readiness assessment in adolescents and young adults with chronic intestinal failure on home parenteral nutrition: A descriptive cross-sectional study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Central line-associated bloodstream infection rates in pediatric short bowel syndrome in the United States: A retrospective cohort study from 2016 to 2023.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- A Multidisciplinary Approach to the Classification and Management of Intestinal Failure: Knowledge in Progress.Diagnostics (Basel, Switzerland) · 2024Review
- Gut microbiota and intestinal rehabilitation: a prospective childhood cohort longitudinal study of short bowel syndrome (the MIRACLS study): study protocol.BMJ open gastroenterology · 2024Article
- Associations between hospital-level socioeconomic patient mix and rates of central line-associated bloodstream infections in short bowel syndrome: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Administration of 4% tetrasodium EDTA lock solution and central venous catheter complications in high-risk pediatric patients with intestinal failure: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Ileal lengthening through internal distraction: A novel procedure for ultrashort bowel syndrome.Journal of pediatric surgery open · 2024Article
- Neighborhood Income Is Associated with Health Care Use in Pediatric Short Bowel Syndrome.The Journal of pediatrics · 2024Article
- Incidence and development of cholestasis in surgical neonates receiving an intravenous mixed-oil lipid emulsion.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Overview of Physical, Neurocognitive, and Psychosocial Outcomes in Pediatric Intestinal Failure and Transplantation.Current gastroenterology reports · 2022Review
- Venous Thromboembolic Complications in Pediatric Gastrointestinal Diseases: Inflammatory Bowel Disease and Intestinal Failure.Frontiers in pediatrics · 2022Review
- HPN Standard of Care and Long-Term Outcomes of CIF Pediatric Patients: Twenty-Eight Years' Experience in a Reference Center.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntestinal failure (IF) is associated with significant morbidity and mortality, yet specific parameters that determine medium- and long-term outcomes remain ill defined.
objectiveThe aim of this study was to determine the long-term outcomes in childhood IF and identify patient characteristics associated with clinical endpoints.
designMEDLINE and EMBASE were searched for cohorts of >10 pediatric-onset IF patients with >12 mo follow-up. Random-effects meta-analysis and meta-regression weighted by follow-up duration were used to calculate clinical outcome rates and patient factors associated with outcomes. Primary outcome was mortality rate; secondary outcomes included neurodevelopmental status, transplantation, IF-associated liver disease (IFALD), enteral autonomy, and sepsis.
resultsIn total, 175 cohorts (9318 patients and 34,549 y follow-up) were included in the meta-analysis. Overall mortality was 5.2% per y (95% CI: 4.3, 6.0) and was associated with sepsis and IFALD on meta-regression. Mortality rate improved with time from 5.9% per y pre-2000 to 4.5% per y post-2005. Sepsis rate was also predictive of IFALD and liver failure. Enteral autonomy was associated with small bowel length but not presence of ileo-cecal valve. There was a relative lack of data on neurodevelopmental outcomes.
conclusionsSepsis is the primary modifiable factor associated with mortality and liver failure, whereas enteral autonomy correlates with small-bowel length. No clear parameters have been identified that accurately predict neurodevelopmental outcomes, and hence further research is needed. Together, our findings are helpful for parental counseling and resource planning, and support targeting reduction in sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.